Theranostic nanoplatforms with accurate diagnosis and effective therapy show a bright prospect for tumor treatments. Herein, a novel boracic acid-modified graphite carbon nitride and Prussian blue nanohybrid (PB@B-g-C₃N₄) was developed, which provides sialic acid-targeted Raman recognition and synergistic photothermal/photodynamic therapy in the near-infrared region. Owing to the specific interaction between boracic acid and sialic acid and Raman response at 2157 cm⁻¹ of PB, the nanohybrids exhibit high specificity and Raman sensitivity for detection of the overexpressed sialic acid on tumor cells. Moreover, the photothermal conversion efficiency of PB@B-g-C₃N₄ is as high as 47.0% with 808 nm laser irradiation due to the enhanced absorbance of PB@B-g-C₃N₄. PB@B-g-C₃N₄ also possesses excellent photodynamic activity, which is attributed to the energy transfer of PB (type I) and electron transfer between PB and B-g-C₃N₄ (type II). This nanotheranostic agent for Raman recognition of cancer markers and synergistic photothermal/photodynamic therapy holds great potential for the development of efficient theranostic nanoplatforms.

具有准确诊断和有效治疗的治疗诊断纳米平台显示出肿瘤治疗的光明前景。在此，开发了一种新型硼酸改性石墨碳氮化碳和普鲁士蓝纳米杂化物（PB@BgC ₃ N ₄），可在近红外区域提供唾液酸靶向拉曼识别和协同光热/光动力治疗。由于硼酸和唾液酸之间的特异性相互作用以及 PB 的 2157 cm ^-1处的拉曼响应，纳米杂化物对检测肿瘤细胞上过表达的唾液酸表现出高特异性和拉曼灵敏度。此外，PB@BgC ₃ N _{4的光热转换效率由于 PB@BgC 3} N ₄的吸光度增强，在 808 nm 激光照射下，吸收率高达 47.0% 。PB@BgC ₃ N ₄还具有优异的光动力学活性，这归因于PB（I型）的能量转移和PB与BgC ₃ N ₄（II型）之间的电子转移。这种用于拉曼识别癌症标志物和协同光热/光动力疗法的纳米治疗剂对于开发有效的治疗诊断纳米平台具有巨大的潜力。