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Near-infrared fluorescent probe based on rhodamine derivative for detection of NADH in live cells
Methods ( IF 4.2 ) Pub Date : 2022-04-02 , DOI: 10.1016/j.ymeth.2022.03.019 Yibin Zhang 1 , Dilka Liyana Arachchige 1 , Adenike Olowolagba 1 , Rudy L Luck 1 , Haiying Liu 1
中文翻译：
基于罗丹明衍生物的近红外荧光探针用于检测活细胞中的NADH
更新日期：2022-04-02
Methods ( IF 4.2 ) Pub Date : 2022-04-02 , DOI: 10.1016/j.ymeth.2022.03.019 Yibin Zhang 1 , Dilka Liyana Arachchige 1 , Adenike Olowolagba 1 , Rudy L Luck 1 , Haiying Liu 1
Affiliation
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A near-infrared fluorescent probe was prepared for selective detection of reduced nicotinamide adenine dinucleotide (NADH) in live cells. The probe turns off the fluorescence with a closed spironolactone switch. However, reduction of the probe by NADH turns on fluorescence at 740 nm. Theoretical calculations suggest a more planar arrangement between the rhodamine and quinoline moieties with increased π-delocalization resulting from reduction.
中文翻译：
基于罗丹明衍生物的近红外荧光探针用于检测活细胞中的NADH
制备了近红外荧光探针，用于选择性检测活细胞中还原型烟酰胺腺嘌呤二核苷酸（NADH）。探针通过闭合的螺内酯开关关闭荧光。然而，探针被 NADH 还原后会在 740 nm 处发出荧光。理论计算表明，罗丹明和喹啉部分之间的排列更加平面，并且由于还原而增加了 π 离域。
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