<br>用于伤口愈合应用的旋转喷射纺负载姜黄素的聚 L-乳酸膜,Journal of Materials Research and Technology

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用于伤口愈合应用的旋转喷射纺负载姜黄素的聚 L-乳酸膜
Journal of Materials Research and Technology ( IF 6.2 ) Pub Date : 2022-04-02 , DOI: 10.1016/j.jmrt.2022.03.136
Karla A. Barbosa ₁ , Isabella C.P. Rodrigues ₂ , Letícia Tamborlin _{1,

3} , Augusto D. Luchessi _{1,

3} , Éder S.N. Lopes ₂ , Laís P. Gabriel ₁

Affiliation

聚合物膜具有高孔隙率和表面积，是伤口愈合应用中传统敷料的良好替代品。将生物活性颗粒掺入膜中可以改善敷料的治疗效果。据报道，姜黄素是一种具有抗氧化和伤口愈合潜力的生物活性颗粒，以及对抗糖尿病、炎症和癌症的治疗作用。然而，很少有技术被探索来大规模有效地生产姜黄素含量的调味品。旋转喷射纺丝（RJS）是一种膜加工技术，因其高纤维生产率而受到关注。在这项研究中，我们旨在生产和表征基于聚 L-乳酸（PLLA）的 RJS 膜与姜黄素颗粒（PLLA-Curc）的伤口治疗适用性。我们生产的膜纤维直径小于 10 μm。这些膜表现出热稳定性、疏水性、足够的机械阻力（适用于局部应用）、低降解率以及 6 小时内姜黄素的显着释放，然后是连续释放曲线。此外，PLLA 和 PLLA-Curc 膜显示出与成纤维细胞的细胞相容性。总之，RJS 是一种获得掺入姜黄素的膜的有效技术，这些膜有可能作为非粘附性局部敷料进行伤口治疗。

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Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applications

Polymeric membranes are good alternatives to conventional dressings for wound-healing applications, owing to their high porosity and surface area. Incorporation of bioactive particles into membranes can improve therapeutic outcomes of dressings. Curcumin has been reported as a bioactive particle with antioxidant and wound-healing potential, as well as therapeutic action against diabetes, inflammation, and cancer. However, few techniques have been explored to efficiently produce curcumin-incorporated dressings on a large scale. Rotary jet spinning (RJS) is a membrane processing technique that has gained attention for its high production rate of fibers. In this study, we aimed to produce and characterize poly(L-lactic acid) (PLLA)-based RJS membranes incorporated with curcumin particles (PLLA-Curc) for wound-treatment suitability. We produced membranes with fiber diameters less than 10 μm. The membranes demonstrated thermal stability, a hydrophobic profile, adequate mechanical resistance for topical application, low degradation rates, and a marked release of curcumin over 6 h, followed by a continuous–release profile. In addition, PLLA and PLLA-Curc membranes showed cytocompatibility with fibroblasts. In summary, RJS is an efficient technique to obtain membranes incorporated with curcumin that have potential for wound treatment as non-adherent topical dressings.

更新日期：2022-04-02

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