Cancer is one of commonly concerned health problems globally and its management is challenging. Besides an availability of diverse classes of anticancer agents, the existing drugs are noted for their limitations such as considerable toxicities, low potency and responsiveness, drug resistance, and others. 1,2,3-Triazole is an attractive heterocyclic scaffold possessing considerable characteristics and is presented in many pharmacologically active molecules. Accordingly, attention has been given to this scaffold in the recent years, especially, in an area of anticancer drug development. In this review, a collection of recently reported triazole based anticancer agents are discussed along with their synthetic methods, proposed molecular targets, and mechanisms of actions. A summary of other recently reported biological activities is also provided. In overview, recent studies suggested that the 1,2,3-triazole based compounds could elicit their anticancer effects against several cancer cell lines via an inhibition of cancer cell growth, an induction of apoptosis, an inhibition of involved enzymes such as aromatase, kinases, and others. Some interesting results from computational studies also discussed relating to the predictions of possible molecular targets. In summary, it is suggested that the 1,2,3-triazole serves as a potential scaffold with noteworthy opportunity for future development of novel anticancer agents to cope with current challenging issues in cancer management.

中文翻译：

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近期医学应用中的 1,2,3-三唑支架：合成和抗癌潜力

癌症是全球普遍关注的健康问题之一，其管理具有挑战性。除了可以使用多种类型的抗癌剂外，现有药物还因其局限性而著称，例如相当大的毒性、低效力和反应性、耐药性等。1,2,3-三唑是一种有吸引力的杂环支架，具有相当大的特性，并存在于许多药理活性分子中。因此，近年来，这种支架受到了关注，特别是在抗癌药物开发领域。在这篇综述中，讨论了最近报道的一系列基于三唑的抗癌药物及其合成方法、提出的分子靶点和作用机制。还提供了其他最近报道的生物活性的摘要。通过抑制癌细胞生长、诱导细胞凋亡、抑制所涉及的酶如芳香酶、激酶等。计算研究的一些有趣结果也与可能的分子目标的预测有关。总之，建议 1,2,3-三唑作为一种潜在的支架，为未来开发新型抗癌剂以应对当前癌症管理中的挑战性问题提供了值得注意的机会。