The low solubility of quercetin considerably decreases its loading efficiency in traditional water and oil-based emulsion systems, which has limited their applications. To find a solution to this issue, in this investigation, polyol consisting of dipropylene glycol and glycerol as a solvent was used to increase quercetin solubility. It was further incorporated in polyol-in-oil-in-water Pickering double emulsions stabilized by SiO₂. The characterization of these Pickering double emulsions was performed by analyses of their microscopic structures, particle sizes, rheology, and storage stability. The rise in the concentration of quercetin from 0 to 0.60 wt% decreased the droplet size of these emulsions and increased their viscoelasticity and storage stability. The microstructure of the emulsions showed the presence of some quercetin on the water-oil interface, suggesting that this bioactive compound might have recrystallized from the internal polyol phase during the preparation and then acted as a particle stabilizer in synergy with SiO₂. To test and validate this hypothesis, we examined the Pickering stabilization properties of the recrystallization quercetin and its interaction with SiO₂. We found that the recrystallized quercetin interacted with SiO₂ through a hydrogen bond and co-stabilized the interface. Additionally, it also served as a thickener that was involved in the development of an intense entangled network structure that connected the droplets, which improved the emulsion stability. These results revealed an effective approach for the preparation of stable Pickering double emulsions with high quercetin loading.

槲皮素的低溶解度显着降低了其在传统水基和油基乳液体系中的负载效率，这限制了它们的应用。为了解决这个问题，在这项调查中，由二丙二醇和甘油组成的多元醇作为溶剂被用来增加槲皮素的溶解度。_{它进一步掺入到 SiO 2}稳定的水包油包多元醇 Pickering 双乳液中. 通过分析它们的微观结构、粒度、流变学和储存稳定性，对这些 Pickering 双乳液进行了表征。槲皮素浓度从 0 到 0.60 wt% 的增加降低了这些乳液的液滴大小并增加了它们的粘弹性和储存稳定性。乳液的微观结构表明在水-油界面上存在一些槲皮素，表明这种生物活性化合物可能在制备过程中从内部多元醇相中重结晶，然后与SiO ₂协同作用作为颗粒稳定剂。为了检验和验证这一假设，我们检查了重结晶槲皮素的皮克林稳定性及其与 SiO _{2的相互作用}. 我们发现重结晶的槲皮素通过氢键与SiO _{2相互作用并共同稳定界面。}此外，它还用作增稠剂，参与形成连接液滴的强烈纠缠网络结构，从而提高乳液稳定性。这些结果揭示了一种制备具有高槲皮素负载量的稳定 Pickering 双乳液的有效方法。