Directed Copper-Catalyzed Tandem Radical Cyclization Reaction of Alkyl Bromides and Unactivated Olefins,Organic Letters

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Directed Copper-Catalyzed Tandem Radical Cyclization Reaction of Alkyl Bromides and Unactivated Olefins
Organic Letters ( IF 4.9 ) Pub Date : 2022-03-31 , DOI: 10.1021/acs.orglett.2c00835
Ming Li ₁ , Yuke Li ₂ , Wan-Yuan Jia ₁ , Guo-Qing Sun ₁ , Fan Gao ₁ , Guo-Xiao Zhao ₁ , Yi-Feng Qiu ₁ , Xi-Cun Wang ₁ , Yong-Min Liang ₃ , Zheng-Jun Quan ₁

Affiliation

The free radical cyclization reaction is a promising strategy for ring framework formation. Herein, we report a copper-catalyzed tandem radical cyclization strategy for preparing substituted lactam derivatives. This reaction proceeds through a radical coupling approach, which not only allows a wide range of alkenes but also is quite compatible with the primary, secondary, and tertiary radicals. In addition, density functional theory calculations were performed to gain insights into the reaction mechanism.

中文翻译：

烷基溴与未活化烯烃的定向铜催化串联自由基环化反应

自由基环化反应是一种很有前景的环骨架形成策略。在此，我们报告了一种铜催化的串联自由基环化策略，用于制备取代的内酰胺衍生物。该反应通过自由基偶联方法进行，不仅允许范围广泛的烯烃，而且与伯、仲和叔自由基非常相容。此外，还进行了密度泛函理论计算以深入了解反应机理。

更新日期：2022-03-31

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