Ectoine is an amino acid derivative and an important natural product in halophilic microorganisms. It plays an important role in protecting cells and stabilizing biological macromolecules, and can be widely used in biomedical fields such as drug preparation adjuvants, organ transplantation and preservation, skin wound repair and cosmetics. Due to the medical value and commercial market demand of ectoine, this article summarized the recent advances in the microbial production of ectoine, including the mutation and breeding of hyper-producing strains, construction of genetically and metabolically engineered strains, optimization of fermentation processes, and extraction and purification processes. The application of multi-omics technologies and computational biology to develop an ectoine producing cell factory was prospected, with the aim to provide a reference for ectoine overproduction.

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[相容溶质四氢嘧啶的微生物生产进展：综述]。

四氢嘧啶是一种氨基酸衍生物，是嗜盐微生物中重要的天然产物。在保护细胞和稳定生物大分子方面具有重要作用，可广泛应用于药物制备佐剂、器官移植与保存、皮肤创面修复、化妆品等生物医学领域。由于四氢嘧啶的医学价值和商业市场需求，本文总结了四氢嘧啶微生物生产的最新进展，包括高产菌株的突变和育种，基因和代谢工程菌株的构建，发酵工艺的优化，以及提取和纯化过程。展望了多组学技术和计算生物学在开发四氢嘧啶生产细胞工厂中的应用，