A high-resolution mass spectrometric approach to a qualitative and quantitative comparative metabolism of the humantenine-type alkaloid rankinidine,Rapid Communications in Mass Spectrometry

当前位置： X-MOL 学术 › Rapid Commun. Mass Spectrom. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A high-resolution mass spectrometric approach to a qualitative and quantitative comparative metabolism of the humantenine-type alkaloid rankinidine
Rapid Communications in Mass Spectrometry ( IF 1.8 ) Pub Date : 2022-03-28 , DOI: 10.1002/rcm.9302
Meng-Die Gong _{1,

2} , Jiao-Yan Qin _{1,

2} , Meng-Ting Zuo _{1,

2} , Xue-Jia Qi _{1,

2} , Yong Wu _{1,

2} , Xiao-Feng Zheng _{1,

2} , Zhao-Ying Liu _{1,

2}

Affiliation

Rankinidine belongs to the humantenine-type alkaloids isolated from Gelsemium. Currently, the mechanism behind the toxicity differences of rankinidine has not been explained. In this study, our purpose was to elucidate the major in vitro metabolic pathways of rankinidine and to compare the formation of metabolites of rankinidine in human (HLMs), rat (RLMs), goat (GLMs) and pig (PLMs) liver microsomes.

中文翻译：

一种高分辨率质谱方法对人汀型生物碱兰基尼定的定性和定量比较代谢

兰基尼定属于从葛根中分离出来的人丁胺类生物碱。目前，兰基尼定毒性差异背后的机制尚未得到解释。在本研究中，我们的目的是阐明兰基尼定的主要体外代谢途径，并比较兰基尼定代谢物在人 (HLM)、大鼠 (RLM)、山羊 (GLM) 和猪 (PLM) 肝微粒体中的形成。

更新日期：2022-03-28

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>