2,5-furandicarboxylic acid (FDCA) has the similar structure with terephthalic acid, and it can be used in the preparation of new furan-based polyamide materials to replace petroleum-based monomer. In present work, polyfuran dicarboxylate decane diamine (PA10F) was prepared from dimethyl 2,5-furandicarboxylate (DMFDCA) and 1,10-diaminodecane, and using PA10F (Mw = 3.3 × 10⁴) as raw material. And then DMF as solvent and water as coagulation bath, PA10F membranes with asymmetric structure were fabricated by non-solvent induced phase separation (NIPS) from different concentration of PA10F casting solution. The performance of PA10F membrane was studied on the morphology, roughness, surface charge, reject rate and anti-protein contamination. The results show that the surface of PA10F is negatively charged, and the rejection rates of methyl blue (MB, Mr = 799.80), Congo red (CR, Mr = 696.68) and acid fuchsin (AF, Mr = 585.54) with different molecular sizes can reach 100%, 99.06% and 98.01%, respectively. Furthermore, PA10F membrane shows an excellent anti-fouling performance, and the flux recovery rate can reach 94.01%.