确定亚油酸在丙烯酸骨水泥中的作用,Journal of Applied Polymer Science

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确定亚油酸在丙烯酸骨水泥中的作用
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2022-03-26 , DOI: 10.1002/app.52409
Thayanithi Ayyachi ₁ , Daniela Pappalardo ₂ , Anna Finne‐Wistrand ₁

Affiliation

聚甲基丙烯酸甲酯在临床上用作各种骨科和创伤手术中的骨水泥。手术后，据报道这种传统的丙烯酸骨水泥会导致邻近的椎骨骨折；通过在配方中添加亚油酸对其进行改性，除了提供方便的处理性能外，由于符合骨骼的机械性能，已显示出避免此类骨折的潜力。尽管由此产生的特性很有吸引力，但对亚油酸如何赋予这些有利特性的理解仍不清楚。亚油酸通常在用于骨水泥制剂之前在高压釜中灭菌；然而，人们担心灭菌是否会导致降解。在这项研究中，¹ H NMR 和 UV-Vis。结果表明，亚油酸由于灭菌而降解。此外，已收集到灭菌/未灭菌亚油酸与活化剂和引发剂反应的证据。我们假设这些反应会降低用于甲基丙烯酸甲酯单体原位聚合的组分的可用性，并导致处理性能的改善和机械性能的降低。

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Defining the role of linoleic acid in acrylic bone cement

Polymethylmethacrylate is clinically used as a bone cement in various orthopedic and trauma surgeries. Post the surgery, such conventional acrylic bone cement has been reported to cause adjacent vertebral fractures; modifying it by adding linoleic acid in the formulation has shown potential in averting such fractures thanks to bone-compliant mechanical properties, besides providing convenient handling properties. Although the resulting properties are attractive, the understanding of how linoleic acid imparts such advantageous properties remain unclear. Linoleic acid is typically sterilized in an autoclave before being used in the bone cement formulation; however, there are apprehensions whether the sterilization causes degradation. In this research, sterilized and unsterilized linoleic acid were evaluated alone and with different components of bone cement, such as activator, initiator, monomer, and inhibitor, and the ensuing structural changes in linoleic acid were monitored through ¹H NMR and UV–Vis. The results reveal that linoleic acid degrade due to sterilization. In addition, evidence for reactions of sterilized/unsterilized linoleic acid with activator and initiator have been collected. We hypothesize that these reactions can reduce the availability of the components for the in situ polymerization of methyl methacrylate monomer and cause the improvement in handling properties and decrease in mechanical properties.

更新日期：2022-03-26

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