当前位置：
X-MOL 学术
›
Bioorg. Med. Chem. Lett.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2010-02-04 , DOI: 10.1016/j.bmcl.2010.01.133 Joseph Rimland , Angela Dunne , Suchete S. Hunjan , Rosemary Sasse , Iain Uings , Dino Montanari , Matilde Caivano , Poonam Shah , David Standing , David Gray , David Brown , William Cairns , Ryan Trump , Paul W. Smith , Nicolas Bertheleme , Pier D’Alessandro , Sheraz Gul , Mythily Vimal , David N. Smith , Stephen P. Watson
中文翻译：
鉴定新型，选择性，非甾体功能性糖皮质激素受体拮抗剂
更新日期：2010-02-04
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2010-02-04 , DOI: 10.1016/j.bmcl.2010.01.133 Joseph Rimland , Angela Dunne , Suchete S. Hunjan , Rosemary Sasse , Iain Uings , Dino Montanari , Matilde Caivano , Poonam Shah , David Standing , David Gray , David Brown , William Cairns , Ryan Trump , Paul W. Smith , Nicolas Bertheleme , Pier D’Alessandro , Sheraz Gul , Mythily Vimal , David N. Smith , Stephen P. Watson
The identification of novel, potent, non-steroidal/small molecule functional GR antagonist GSK1564023A selective over PR is described. Associated structure–activity relationships and the process of optimisation of an initial HTS hit are also described.
中文翻译：
鉴定新型，选择性，非甾体功能性糖皮质激素受体拮抗剂
描述了对PR有选择性的新型有效非甾体/小分子功能GR拮抗剂GSK1564023A的鉴定。还描述了相关的结构-活性关系和初始HTS命中的优化过程。
京公网安备 11010802027423号