Zinc-thiazole is a new fungicide that was independently developed in China and has a high efficiency and low toxicity. A modified derivatization method was established to measure zinc-thiazole in foods of plant origin. Zinc-thiazole decomposed into 2-amino-5-mercapto-1,3,4-thiadiazole (AMT) under alkaline conditions, and the AMT was extracted with acidic acetonitrile (pH = 3). The AMT was quantitated by HPLC–MS/MS, and then the amount of zinc-thiazole residue was calculated. Good linearity (R² > 0.9997) was obtained in 0.001–1 mg/L. The limit of quantification of zinc-thiazole was 0.02 mg/kg in peaches, grapes, brown rice and soybeans. A qualified accuracy (recoveries of 75%–90%) and precision (RSD of 1%–5%) were obtained at three fortified levels. This method was applied to peach samples collected from farmland, and the zinc-thiazole residues complied with the residue limits. In the future, this method could be used to analyze residues and in the risk assessment of metal-thiazole fungicides.

噻唑锌是我国自主研发的新型杀菌剂，具有高效、低毒的特点。建立了一种改进的衍生化方法来测量植物源性食品中的锌噻唑。锌-噻唑在碱性条件下分解为2-氨基-5-巯基-1,3,4-噻二唑(AMT)，用酸性乙腈(pH = 3)萃取AMT。通过 HPLC-MS/MS 对 AMT 进行定量，然后计算锌-噻唑残留量。良好的线性度（R ² > 0.9997) 在 0.001–1 mg/L 中获得。桃、葡萄、糙米和大豆中锌噻唑的定量限为 0.02 mg/kg。在三个强化水平上获得了合格的准确度（回收率为 75%–90%）和精密度（RSD 为 1%–5%）。该方法适用于农田桃样品，锌噻唑残留量符合残留限量。将来，该方法可用于分析残留物和金属噻唑类杀菌剂的风险评估。