Self-Assembly of Naturally Small Molecules into Supramolecular Fibrillar Networks for Wound Healing,Advanced Healthcare Materials

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Self-Assembly of Naturally Small Molecules into Supramolecular Fibrillar Networks for Wound Healing
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2022-03-20 , DOI: 10.1002/adhm.202102476
Haibo Huang ₁ , Wei Gong ₂ , Xinchuang Wang ₁ , Wanying He ₁ , Yiyang Hou ₁ , Jiangning Hu _{1,

2}

Affiliation

Self-assemblies of bioactively natural compounds into supramolecular hydrogels without structural modifications are of interest to improve their sustained releases and bioavailabilities in vivo. However, it is still a formidable challenge to dig out such a naturally small molecule with a meticulous structure which can be self-assembled to form a hydrogel for biomedical applications. Here, a new hydrogel consisting only of gallic acid (GA) via π–π stacking and hydrogen bond interactions, whereas none of GA analogues can form the similar supramolecular hydrogels, is reported. This interesting phenomenon is intriguing to further investigate the potential applications of GA hydrogels in wound healing. Notably, this GA hydrogel has rod-like structures with lengths varying from 10 to 100 µm. The biocompatibility and antibacterial tests prove that this well-assembled GA hydrogel has no cytotoxicity and excellent antibacterial activities against Escherichia coli and Staphylococcus aureus. Moreover, the GA hydrogel can significantly accelerate the process of wound healing with or without bacterial infections by mediation of inflammation signaling pathways. It is believed that the current study may shed a new light on the design of a supramolecular hydrogel based on self-assemblies of naturally small molecules to improve their bioavailabilities and diversify their uses in biomedical applications.

中文翻译：

将天然小分子自组装成超分子纤维网络用于伤口愈合

将具有生物活性的天然化合物自组装成超分子水凝胶而无需进行结构修饰，以提高其在体内的持续释放和生物利用度。然而，要挖掘出这样一种具有精细结构的天然小分子，可以自组装形成用于生物医学应用的水凝胶，仍然是一项艰巨的挑战。在这里，一种仅由没食子酸 (GA) 通过π – π组成的新型水凝胶据报道，堆叠和氢键相互作用，而 GA 类似物都不能形成类似的超分子水凝胶。这种有趣的现象对于进一步研究 GA 水凝胶在伤口愈合中的潜在应用很有吸引力。值得注意的是，这种 GA 水凝胶具有棒状结构，长度从 10 到 100 µm 不等。生物相容性和抗菌性测试证明，这种组装良好的GA水凝胶对大肠杆菌和金黄色葡萄球菌没有细胞毒性和优异的抗菌活性. 此外，GA 水凝胶可以通过介导炎症信号通路显着加速有或没有细菌感染的伤口愈合过程。相信目前的研究可能为基于天然小分子自组装的超分子水凝胶的设计提供新的思路，以提高其生物利用度并使其在生物医学应用中的用途多样化。

更新日期：2022-03-20

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