由铈（III、IV）氧化物矿化蛋壳膜制成的智能仿生骨膜,ACS Applied Materials & Interfaces

当前位置： X-MOL 学术 › ACS Appl. Mater. Interfaces › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

由铈（III、IV）氧化物矿化蛋壳膜制成的智能仿生骨膜
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2022-03-19 , DOI: 10.1021/acsami.2c02079
Qian-Qian Wan ₁ , Kai Jiao ₁ , Yu-Xuan Ma ₁ , Bo Gao ₂ , Zhao Mu ₁ , Yi-Rong Wang ₁ , Yan-Hao Wang ₃ , Lian Duan ₄ , Ke-Hui Xu ₁ , Jun-Ting Gu ₁ , Jian-Fei Yan ₁ , Jing Li ₁ , Min-Juan Shen ₁ , Franklin R Tay ₅ , Li-Na Niu _{1,

6}

Affiliation

骨膜协调骨再生的微环境，包括促进局部神经血管形成和调节免疫反应。为了模拟天然骨膜在增强骨修复中的作用，我们首次采用仿生矿化原理将无定形氧化铈精细嵌入蛋壳膜 (ESM) 中。氧化铈中的铈具有独特的能力，可以将其氧化态从铈 III 转换为铈 IV，反之亦然，这为生物医学应用提供了广阔的潜力。ESM 用氧化铈 (III, IV) 矿化并检查其生物相容性。除了作为物理屏障外，骨膜状铈（III，IV) 氧化物矿化 ESM 具有生物相容性，可以在小鼠颅骨缺损模型中主动调节免疫反应并促进局部神经血管形成以及早期骨再生。在愈合过程中，嵌铈仿生骨膜可以促进巨噬细胞系细胞的早期破骨细胞分化，这可能是局部修复微环境的主要介质。目前的工作为扩展仿生骨膜的定义和功能提供了新的见解，以促进早期骨修复并通过强大的神经血管化优化长期修复。这种采用多功能骨和骨膜模拟系统的新治疗策略创造了一个高度协调的微环境，以加速骨再生。

"点击查看英文标题和摘要"

Smart, Biomimetic Periosteum Created from the Cerium(III, IV) Oxide-Mineralized Eggshell Membrane

The periosteum orchestrates the microenvironment of bone regeneration, including facilitating local neuro-vascularization and regulating immune responses. To mimic the role of natural periosteum for bone repair enhancement, we adopted the principle of biomimetic mineralization to delicately inlay amorphous cerium oxide within eggshell membranes (ESMs) for the first time. Cerium from cerium oxide possesses unique ability to switch its oxidation state from cerium III to cerium IV and vice versa, which provides itself promising potential for biomedical applications. ESMs are mineralized with cerium(III, IV) oxide and examined for their biocompatibility. Apart from serving as physical barriers, periosteum-like cerium(III, IV) oxide-mineralized ESMs are biocompatible and can actively regulate immune responses and facilitate local neuro-vascularization along with early-stage bone regeneration in a murine cranial defect model. During the healing process, cerium-inlayed biomimetic periosteum can boost early osteoclastic differentiation of macrophage lineage cells, which may be the dominant mediator of the local repair microenvironment. The present work provides novel insights into expanding the definition and function of a biomimetic periosteum to boost early-stage bone repair and optimize long-term repair with robust neuro-vascularization. This new treatment strategy which employs multifunctional bone-and-periosteum-mimicking systems creates a highly concerted microenvironment to expedite bone regeneration.

更新日期：2022-03-19

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南