Catalyst- and Solvent-Free Synthesis of N-Acylhydrazones via Solid-State Melt Reaction,Asian Journal of Organic Chemistry

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Catalyst- and Solvent-Free Synthesis of N-Acylhydrazones via Solid-State Melt Reaction
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2022-03-18 , DOI: 10.1002/ajoc.202200117
Pipattra Mayurachayakul ₁ , Nakorn Niamnont ₁ , Kittichai Chaiseeda ₁ , Oraphin Chantarasriwong ₂

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N-acylhydrazones were successfully synthesized by solid-state melt reactions of aromatic aldehydes with 2-furoic hydrazide, 2-thiophenecarboxylic acid hydrazide or substituted alkyl/aryl-acylhydrazides. No catalysts and solvents were needed for the reaction. Compared to previously reported methods, our method gives higher product yields and has faster reaction times. It could be scaled up and has high atom economy, high reaction mass efficiency, low E-factor, and low process mass intensity. These encourage green chemistry principles and sustainable synthetic chemistry.

中文翻译：

通过固态熔融反应无催化剂和无溶剂合成 N-酰基腙

N-酰基腙通过芳香醛与2-糠酸酰肼、2-噻吩羧酸酰肼或取代烷基/芳基酰肼的固态熔融反应成功合成。该反应不需要催化剂和溶剂。与以前报道的方法相比，我们的方法产生了更高的产品收率和更快的反应时间。它可以按比例放大，具有高原子经济性、高反应质量效率、低 E 因子和低工艺质量强度。这些鼓励绿色化学原则和可持续合成化学。

更新日期：2022-03-18

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