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Design of 1-(2-pyrrolidinone)-butane-1,3-dione derivatives and acetoxylation of these compound's methylene via hypervalent iodine (III)
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2022-03-17 , DOI: 10.1002/jhet.4482 Furgan Aslanoğlu 1
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2022-03-17 , DOI: 10.1002/jhet.4482 Furgan Aslanoğlu 1
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An interesting synthesis method for 2-acetate-1-(2-pyrrolidinone)-butane-1,3-dione compounds was developed in this work. The synthesis of these compounds was carried out in three steps. In the first step, 2-pyrrolidone derivatives were obtained by the Friedel-Crafts reaction in presence of Eaton's reagent. Then, -NH group of 2-pyrrolidone compounds were attached acetoacetate group in presence of 2,6-trimethyl-4H-1,3-dioxin-4-one reagent. Lastly, 1-(2-pyrrolidinone)-butane-1,3-dione derivatives were reacted with Pida to attach acetoxy group to these compound's methylene.
中文翻译：
1-(2-吡咯烷酮)-丁烷-1,3-二酮衍生物的设计和这些化合物的亚甲基通过高价碘(III)的乙酰氧基化
本工作开发了一种有趣的 2-乙酸酯-1-(2-吡咯烷酮)-丁烷-1,3-二酮化合物的合成方法。这些化合物的合成分三个步骤进行。第一步，在伊顿试剂存在下，通过傅克反应得到2-吡咯烷酮衍生物。然后，2-吡咯烷酮化合物的-NH基团在2,6-trimethyl-4 H -1,3-dioxin-4-one试剂存在下与乙酰乙酸基团相连。最后，1-(2-吡咯烷酮)-丁烷-1,3-二酮衍生物与Pida反应以将乙酰氧基连接到这些化合物的亚甲基上。
更新日期：2022-03-17
中文翻译：
1-(2-吡咯烷酮)-丁烷-1,3-二酮衍生物的设计和这些化合物的亚甲基通过高价碘(III)的乙酰氧基化
本工作开发了一种有趣的 2-乙酸酯-1-(2-吡咯烷酮)-丁烷-1,3-二酮化合物的合成方法。这些化合物的合成分三个步骤进行。第一步，在伊顿试剂存在下，通过傅克反应得到2-吡咯烷酮衍生物。然后，2-吡咯烷酮化合物的-NH基团在2,6-trimethyl-4 H -1,3-dioxin-4-one试剂存在下与乙酰乙酸基团相连。最后，1-(2-吡咯烷酮)-丁烷-1,3-二酮衍生物与Pida反应以将乙酰氧基连接到这些化合物的亚甲基上。
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