The present work demonstrates a palladium-catalyzed kinetic resolution/ring-opening reaction of 8H-indeno[1,2-c]thiophen-8-ols. The reaction proceeds in a highly regioselective manner, and both optically active thiophene-phenyl atropisomers and stereogenic 8H-indeno[1,2-c]thiophen-8-ols were obtained with high enantiomeric excesses. The synthetic applications of the obtained thiophenyl atropisomers were briefly investigated.

中文翻译：

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8H-茚并[1,2-c]噻吩-8-醇通过Pd催化的C-C键断裂反应的旋转选择性动力学拆分

本工作展示了钯催化的 8 H-茚并[1,2 - c ]噻吩-8-醇的动力学拆分/开环反应。该反应以高度区域选择性的方式进行，并且以高对映体过量获得了光学活性噻吩-苯基阻转异构体和立体异构 8 H-茚并[1,2 - c ]噻吩-8-醇。简要研究了所得噻吩阻转异构体的合成应用。