Identification of Ziyuglycoside II from a Natural Products Library as a STING Agonist,ChemMedChem

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Identification of Ziyuglycoside II from a Natural Products Library as a STING Agonist
ChemMedChem ( IF 3.6 ) Pub Date : 2022-03-15 , DOI: 10.1002/cmdc.202100719
Xiangling Cui _{1,

2} , Yongli Xie ₂ , Min Zhang ₁ , Jieke Gao ₁ , Xujun Zhou ₁ , Jiwei Ding ₂ , Shan Cen ₂ , Jinming Zhou _{1,

2}

Affiliation

Hitting where it STINGs: Stimulator of interferon genes (STING) is a promising target for drug development. We identified a small-molecular STING agonist, ziyuglycoside II, termed ST12, with a novel core structure and potent stimulation of the IRF/IFN and NF-κB pathways. ST12′s binding to the C-terminal domain of human STING, as detected by bio-layer interferometry, indicates that ST12 is a human STING agonist. This study shows that ST12 is a suitable lead compound for further optimization. OK

中文翻译：

从天然产物库中鉴定紫玉糖苷 II 作为 STING 激动剂

击中它的 STING 位置：干扰素基因刺激物 (STING) 是药物开发的一个有前途的目标。我们鉴定了一种名为 ST12 的小分子 STING 激动剂 ziyuglycoside II，它具有新的核心结构和对 IRF/IFN 和 NF-κB 通路的有效刺激。生物层干涉仪检测到 ST12 与人 STING 的 C 末端结构域的结合表明 ST12 是人 STING 激动剂。这项研究表明，ST12 是一种适合进一步优化的先导化合物。好的

更新日期：2022-03-15

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