Hitting where it STINGs: Stimulator of interferon genes (STING) is a promising target for drug development. We identified a small-molecular STING agonist, ziyuglycoside II, termed ST12, with a novel core structure and potent stimulation of the IRF/IFN and NF-κB pathways. ST12′s binding to the C-terminal domain of human STING, as detected by bio-layer interferometry, indicates that ST12 is a human STING agonist. This study shows that ST12 is a suitable lead compound for further optimization. OK

中文翻译：

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从天然产物库中鉴定紫玉糖苷 II 作为 STING 激动剂

击中它的 STING 位置：干扰素基因刺激物 (STING) 是药物开发的一个有前途的目标。我们鉴定了一种名为 ST12 的小分子 STING 激动剂 ziyuglycoside II，它具有新的核心结构和对 IRF/IFN 和 NF-κB 通路的有效刺激。生物层干涉仪检测到 ST12 与人 STING 的 C 末端结构域的结合表明 ST12 是人 STING 激动剂。这项研究表明，ST12 是一种适合进一步优化的先导化合物。好的