光动力疗法：关键 PDT 理论†,Photochemistry and Photobiology

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光动力疗法：关键 PDT 理论†
Photochemistry and Photobiology ( IF 2.6 ) Pub Date : 2022-03-15 , DOI: 10.1111/php.13616
David Kessel ₁

Affiliation

光动力疗法可用于根除光传递可及部位的恶性细胞。不良反应很少，许多临床报告表明 PDT 具有治愈潜力。推广其他方案的人也会寻找疾病较轻的患者，成功的可能性更大。不断发现引发光催化反应的新光敏剂。描述光生物学基本方面的进展的报告总是很有趣。但是，治疗肿瘤和其他疾病的意义并不总是合理的，尤其是当使用穿透性差的光波长时，通常是在非常高的光剂量下。有时通过可能无法准确测量光致杀伤的方案来估计功效。许多声称与体外观察具有潜在临床相关性的报告是基于对临床疗效决定因素的有限理解。光动力疗法的未来取决于对可以完成什么的认识，尤其是当与其他方式一起使用时，但也将取决于资助机构、制药集团和临床人员的目标和利益。本评论旨在提供对当前研究工作的一些想法，尤其是在建议、暗示或以其他方式暗示临床意义的地方。但也将取决于资助机构、制药集团和临床人员的目标和利益。本评论旨在提供对当前研究工作的一些想法，尤其是在建议、暗示或以其他方式暗示临床意义的地方。但也将取决于资助机构、制药集团和临床人员的目标和利益。本评论旨在提供对当前研究工作的一些想法，尤其是在建议、暗示或以其他方式暗示临床意义的地方。

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Photodynamic Therapy: Critical PDT Theory†

Photodynamic therapy can be useful for the eradication of malignant cells at sites that are accessible to light delivery. There are few adverse effects, with many clinical reports indicating that PDT has curative potential. Patients with minimal disease, where success is more likely, are also sought by those promoting other protocols. New photosensitizing agents that initiate light-catalyzed reactions continue to be discovered. Reports describing advances in understanding fundamental aspects of photobiology are always of interest. But, implications for treatment of neoplasia and other diseases are not always justified, especially when poorly penetrating wavelengths of light are employed, often at very high light doses. Efficacy is sometimes estimated by protocols that may not accurately measure photokilling. Many reports claiming potential clinical relevance for in vitro observations are based on a limited understanding of the determinants of clinical efficacy. The future of photodynamic therapy depends on an appreciation of what can be accomplished, especially when used with other modalities, but will also depend on the goals and interests of granting agencies, pharmaceutical groups, and clinical personnel. This commentary is intended to provide some thoughts on current research efforts, especially where clinical implications are suggested, hinted at or otherwise implied.

更新日期：2022-03-15

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