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Synthesis and anti-inflammatory evaluation of some condensed [4-(3,4-dimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide
European Journal of Medicinal Chemistry ( IF 6.0 ) Pub Date : 2009-10-23 , DOI: 10.1016/j.ejmech.2009.10.028
Mosaad S.M. Abd alla , Mohamed I. Hegab , Nageh A. Abo Taleb , Sherifa M. Hasabelnaby , A. Goudah

Some new 1,3,4-triazolo-, 1,3,4-oxadiazolo-, 1,3,4-thiadiazol-, and pyrazolo-3,4-dimethylphenyl-1(2H)-oxo-phthalazine derivatives were synthesized and identified by IR, 1H NMR, MS and elemental analysis. Most of the newly synthesized products were tested for their anti-inflammatory activities. Among them, compounds 11, 17b, 20, 21 and 22 are active compare to the activity of indomethacin®.



中文翻译:

某些缩合的[4-(3,4-二甲基苯基)-1(2 H)-氧代酞菁-2-基]乙酸酰肼的合成及抗炎性评估

合成了一些新的1,3,4-三唑-,1,3,4-恶二唑-,1,3,4-噻二唑-和吡唑并3,4-二甲基苯基-1(2 H)-氧代-邻苯二嗪衍生物并通过IR,1 H NMR,MS和元素分析鉴定。测试了大多数新合成的产品的抗炎活性。其中,化合物1117B202122是活动的比较吲哚美辛的活性®

更新日期:2009-10-23
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