Ionic Liquids for Enhanced Drug Delivery: Recent Progress and Prevailing Challenges,Molecular Pharmaceutics

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Ionic Liquids for Enhanced Drug Delivery: Recent Progress and Prevailing Challenges
Molecular Pharmaceutics ( IF 4.5 ) Pub Date : 2022-03-11 , DOI: 10.1021/acs.molpharmaceut.1c00960
Chunxia Liu ₁ , Bin Chen ₁ , Wei Shi ₁ , Wenlong Huang _{1,

2} , Hai Qian _{1,

2}

Affiliation

Ionic liquids (ILs) are a class of nonmolecular compounds composed only of ions. Compared with traditional organic solvents, ILs have the advantages of wide chemical space, diverse and flexible structures, negligible vapor pressure, and high thermal stability, which make them widely used in many fields of modern science, such as chemical synthesis and catalytic decomposition, electrochemistry, biomass conversion, and biotransformation biotechnology. Because of their special characteristics, ILs have been favored in the pharmaceutical field recently, especially for the development of efficient drug delivery systems. So far, ILs have been successfully designed to promote the dissolution of poorly soluble drugs and the destruction of physiological barriers, such as the tight junction between the stratum corneum and the intestinal epithelium. In addition, ILs can also be combined with other drug strategies to stabilize the structure of small molecules. This Review mainly introduces the application of ILs in drug delivery, emphasizes the potential mechanism of ILs, and presents the key research directions of ILs in the future.

中文翻译：

用于增强药物输送的离子液体：最近的进展和普遍存在的挑战

离子液体 (ILs) 是一类仅由离子组成的非分子化合物。与传统有机溶剂相比，离子液体具有化学空间宽、结构多样灵活、蒸气压可忽略、热稳定性高等优点，使其广泛应用于现代科学的诸多领域，如化学合成与催化分解、电化学等。、生物质转化和生物转化生物技术。由于其特殊的特性，ILs 最近在制药领域受到青睐，特别是用于开发高效的药物递送系统。到目前为止，ILs 已成功设计用于促进难溶性药物的溶解和生理屏障的破坏，例如角质层和肠上皮细胞之间的紧密连接。此外，ILs 还可以与其他药物策略相结合，以稳定小分子的结构。本综述主要介绍了ILs在药物递送中的应用，强调了ILs的潜在作用机制，并提出了ILs未来的重点研究方向。

更新日期：2022-03-11

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