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2,2,2-Trifluoroacetaldehyde O-(Aryl)oxime: A Precursor of Trifluoroacetonitrile
Organic Letters ( IF 4.9 ) Pub Date : 2022-03-10 , DOI: 10.1021/acs.orglett.2c00637 Bo Lin 1, 2 , Yunfei Yao 2 , Yangjie Huang 1 , Zhiqiang Weng 1, 2
Organic Letters ( IF 4.9 ) Pub Date : 2022-03-10 , DOI: 10.1021/acs.orglett.2c00637 Bo Lin 1, 2 , Yunfei Yao 2 , Yangjie Huang 1 , Zhiqiang Weng 1, 2
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The preparation of 2,2,2-trifluoroacetaldehyde O-(aryl)oxime, a previously inaccessible precursor of trifluoroacetonitrile, via reaction of hydroxylamine and trifluoroacetaldehyde hydrate is reported. This precursor released CF3CN in quantitative yield under mildly basic conditions. The precursor was successfully used in the synthesis of trifluoromethylated oxadiazoles. The facile, cost-effective, scalable, and recyclable procedure makes these trifluoroacetonitrile precursors generally applicable.
中文翻译：
2,2,2-三氟乙醛 O-(芳基)肟：三氟乙腈的前体
报道了通过羟胺和三氟乙醛水合物的反应制备2,2,2-三氟乙醛O- (芳基)肟，这是一种以前难以获得的三氟乙腈前体。该前体在弱碱性条件下以定量产率释放CF 3 CN。该前体成功地用于三氟甲基化恶二唑的合成。简便、经济、可扩展和可回收的程序使这些三氟乙腈前体普遍适用。
更新日期：2022-03-10
中文翻译：
2,2,2-三氟乙醛 O-(芳基)肟：三氟乙腈的前体
报道了通过羟胺和三氟乙醛水合物的反应制备2,2,2-三氟乙醛O- (芳基)肟，这是一种以前难以获得的三氟乙腈前体。该前体在弱碱性条件下以定量产率释放CF 3 CN。该前体成功地用于三氟甲基化恶二唑的合成。简便、经济、可扩展和可回收的程序使这些三氟乙腈前体普遍适用。
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