The preparation of 2,2,2-trifluoroacetaldehyde O-(aryl)oxime, a previously inaccessible precursor of trifluoroacetonitrile, via reaction of hydroxylamine and trifluoroacetaldehyde hydrate is reported. This precursor released CF₃CN in quantitative yield under mildly basic conditions. The precursor was successfully used in the synthesis of trifluoromethylated oxadiazoles. The facile, cost-effective, scalable, and recyclable procedure makes these trifluoroacetonitrile precursors generally applicable.

中文翻译：

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2,2,2-三氟乙醛 O-(芳基)肟：三氟乙腈的前体

报道了通过羟胺和三氟乙醛水合物的反应制备2,2,2-三氟乙醛O- (芳基)肟，这是一种以前难以获得的三氟乙腈前体。该前体在弱碱性条件下以定量产率释放CF _{3 CN。}该前体成功地用于三氟甲基化恶二唑的合成。简便、经济、可扩展和可回收的程序使这些三氟乙腈前体普遍适用。