Anti-inflammatory, anti-angiogenetic and antiviral activities of dammarane-type triterpenoid saponins from the roots of Panax notoginseng,Food & Function

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Anti-inflammatory, anti-angiogenetic and antiviral activities of dammarane-type triterpenoid saponins from the roots of Panax notoginseng
Food & Function ( IF 5.1 ) Pub Date : 2022-03-08 , DOI: 10.1039/d1fo04089h
Yuan-Ru Zheng ₁ , Chun-Lin Fan ₂ , Ye Chen ₂ , Jing-Yu Quan ₁ , Ling-Zhu Shi ₁ , Chun-Yang Tian ₁ , Xiao Shang ₂ , Ni-Shan Xu ₁ , Wen-Cai Ye ₂ , Lin-Zhong Yu ₁ , Jun-Shan Liu _{1,

3}

Affiliation

Panax notoginseng has been used both as a traditional medicine and as a functional food for hundreds of years in Asia. However, the active constituents from P. notoginseng and their pharmacologic properties still need to be further explored. In this study, one new dammarane-type triterpenoid saponin (1), along with fourteen known analogs (2–15) were isolated and identified from the roots of P. notoginseng. The anti-inflammatory, anti-angiogenetic and anti-dengue virus effects of these isolated compounds were further evaluated. Compounds 1, 3, 5–7 and 10–12 exerted anti-inflammatory effects in two different zebrafish inflammatory models. Among them, 11, with the most significant activities, alleviated the inflammatory response by blocking the MyD88/NF-κB and STAT3 pathways. Moreover, compound 15 showed anti-angiogenetic activities in Tg(fli1:EGFP) and Tg(flk1:GFP) zebrafish, while 3 and 5 only inhibited angiogenesis in Tg(fli1:EGFP) zebrafish. Additionally, compounds 1, 3, 6, 8, 9 and 12 suppressed the replication of dengue virus either at the viral adsorption and entry stages or at the intracellular replication step. In conclusion, these findings enrich knowledge of the diversity of saponins in P. notoginseng and suggest that the dammarane-type triterpenoid saponins from P. notoginseng may be developed as potential functional foods to treat inflammation, angiogenesis or dengue-related diseases.

中文翻译：

三七根达玛烷型三萜皂苷的抗炎、抗血管生成和抗病毒活性

三七在亚洲被用作传统药物和功能食品已有数百年历史。然而，三七的活性成分及其药理特性仍需进一步探索。在本研究中，从三七根中分离并鉴定出一种新的达玛烷型三萜皂苷 ( 1 ) 以及 14 种已知类似物 ( 2-15 )。进一步评估了这些分离化合物的抗炎、抗血管生成和抗登革热病毒作用。化合物1、3、5-7和 10-12在两种不同的斑马鱼炎症模型中发挥抗炎作用。其中， 11具有最显着的活性，通过阻断 MyD88/NF-κB 和 STAT3 途径减轻炎症反应。此外，化合物15在Tg( fli1:EGFP )和Tg( flk1:GFP )斑马鱼中表现出抗血管生成活性，而3和5仅抑制Tg( fli1:EGFP )斑马鱼的血管生成。另外，化合物1、3、6、8、9和12在病毒吸附和进入阶段或在细胞内复制步骤抑制登革热病毒的复制。总之，这些发现丰富了对三七皂苷多样性的认识，并表明三七中的达玛烷型三萜皂苷。三七可能被开发为治疗炎症、血管生成或登革热相关疾病的潜在功能性食品。

更新日期：2022-03-08

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