用于体内过氧化氢酶模拟活性和多模态生物成像的超小型锰铁氧体,Small

当前位置： X-MOL 学术 › Small › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

用于体内过氧化氢酶模拟活性和多模态生物成像的超小型锰铁氧体
Small ( IF 13.0 ) Pub Date : 2022-03-08 , DOI: 10.1002/smll.202106570
Susana Carregal-Romero _{1,

2} , Ana Beatriz Miguel-Coello ₁ , Lydia Martínez-Parra ₁ , Yolanda Martí-Mateo ₃ , Pablo Hernansanz-Agustín ₃ , Yilian Fernández-Afonso _{4,

5,

6} , Sandra Plaza-García ₁ , Lucía Gutiérrez _{4,

5,

6} , María Del Mar Muñoz-Hernández ₃ , Juliana Carrillo-Romero ₁ , Marina Piñol-Cancer _{1,

2} , Pierre Lecante ₇ , Zuriñe Blasco-Iturri ₁ , Lucía Fadón _{1,

8} , Ana C Almansa-García ₁ , Marco Möller ₁ , Dorleta Otaegui ₁ , Jose Antonio Enríquez _{3,

9} , Hugo Groult ₁₀ , Jesús Ruíz-Cabello _{1,

2,

11,

12}

Affiliation

Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), San Sebastián, 20014, Spain.
CIBER de Enfermedades Respiratorias (CIBERES), Madrid, 28029, Spain.
Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, 28029, Spain.
Departamento de Química Analítica, Universidad de Zaragoza, Zaragoza, 50009, Spain.
Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Zaragoza, 50009, Spain.
Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Zaragoza, 50009, Spain.
CEMES-CNRS, Université de Toulouse, UPR 8011 CNRS, Toulouse, 31055, France.
Center for Cooperative Research in Bioscience (CIC bioGUNE), Building 800, Science and Technology Park of Bizkaia, Derio, 48160, Spain.
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, 28029, Spain.
BCBS team (Biotechnologies et Chimie des Bioressources pour la Santé), LIENSs Laboratory (Littoral environment et Sociétés), UMR CNRS 7266, La Rochelle, 17000, France.
Ikerbasque, Basque Foundation for Science, Bilbao, 48013, Spain.
Departamento de Química en Ciencias Farmacéuticas, Universidad Complutense de Madrid, Madrid, 28040, Spain.

锰铁氧体纳米粒子在生物成像和催化疗法中显示出有趣的特征。它们最近已在治疗诊断学中用作磁共振成像 (MRI) 中的造影剂，以及用作缓解缺氧的过氧化氢酶模拟纳米酶。这些有前途的应用鼓励开发新的合成程序，以同时增强这些纳米材料的生物成像和催化性能。在此，开发了一种具有成本效益的合成微波方法，用于制造超小型锰铁氧体纳米颗粒，作为 MRI 和正电子发射断层扫描 (PET) 中的先进多模态造影剂，以及改进的纳米酶。这种合成方法允许在宽化学计量范围内（Mn _x Fe _3-_x O ₄, 0.1 ≤ x ≤ 2.4)，提供了具有不同磁弛豫和催化性能的纳米粒子库。这些经过调整的磁性会产生正模或双模 MRI 造影剂。另一方面，较高水平的 Mn 掺杂提高了所得纳米酶的催化效率。最后，通过它们的细胞内过氧化氢酶模拟活性，这些超小的锰铁氧体纳米颗粒在乳腺癌小鼠模型中诱导了前所未有的肿瘤生长抑制。所有这些结果都显示了这些纳米粒子在纳米生物技术应用中的强大特性。

"点击查看英文标题和摘要"

Ultrasmall Manganese Ferrites for In Vivo Catalase Mimicking Activity and Multimodal Bioimaging

Manganese ferrite nanoparticles display interesting features in bioimaging and catalytic therapies. They have been recently used in theranostics as contrast agents in magnetic resonance imaging (MRI), and as catalase-mimicking nanozymes for hypoxia alleviation. These promising applications encourage the development of novel synthetic procedures to enhance the bioimaging and catalytic properties of these nanomaterials simultaneously. Herein, a cost-efficient synthetic microwave method is developed to manufacture ultrasmall manganese ferrite nanoparticles as advanced multimodal contrast agents in MRI and positron emission tomography (PET), and improved nanozymes. Such a synthetic method allows doping ferrites with Mn in a wide stoichiometric range (Mn_xFe_3-_xO₄, 0.1 ≤ x ≤ 2.4), affording a library of nanoparticles with different magnetic relaxivities and catalytic properties. These tuned magnetic properties give rise to either positive or dual-mode MRI contrast agents. On the other hand, higher levels of Mn doping enhance the catalytic efficiency of the resulting nanozymes. Finally, through their intracellular catalase-mimicking activity, these ultrasmall manganese ferrite nanoparticles induce an unprecedented tumor growth inhibition in a breast cancer murine model. All of these results show the robust characteristics of these nanoparticles for nanobiotechnological applications.

更新日期：2022-03-08

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南