Modular Access to Diverse Chemiluminescent Dioxetane-Luminophores through Convergent Synthesis,Angewandte Chemie International Edition

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Modular Access to Diverse Chemiluminescent Dioxetane-Luminophores through Convergent Synthesis
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-03-08 , DOI: 10.1002/anie.202202187
Samer Gnaim _{1,

2} , Sachin Popat Gholap ₁ , Liang Ge ₁ , Sayantan Das ₁ , Sara Gutkin ₁ , Ori Green ₁ , Omri Shelef ₁ , Nir Hananya ₁ , Phil S Baran ₂ , Doron Shabat ₁

Affiliation

A new efficient synthetic route for preparation of adamantyl-enolether as precursors for dioxetane chemiluminescent luminophores was developed. The synthesis is convergent, using an unusual Stille cross-coupling reaction employing a stannane-enolether, to directly afford adamantyl-enolether. The scope of this synthetic route is broad since a large number of haloaryl substrates are either commercially available or easily accessible.

中文翻译：

通过聚合合成模块化获取多种化学发光二氧杂环丁烷发光团

开发了一种新的有效合成路线，用于制备金刚烷基烯醇醚作为二氧杂环丁烷化学发光发光体的前体。该合成是收敛的，使用一种不寻常的 Stille 交叉偶联反应，采用锡烷烯醇醚，直接提供金刚烷基烯醇醚。这种合成路线的范围很广，因为大量的卤代芳基底物要么是商业上可获得的，要么是容易获得的。

更新日期：2022-03-08

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