A simple method had been developed through O-chitosan quaternary ammonium salt (O-HACC), polyvinyl alcohol (PVA) and graphene oxide (GO) to prepare O-HACC/PVA/GO dual self-healing bacteriostatic hydrogels. Then the hydrogels and materials were characterized by FT-IR, X-RD, ¹H NMR, SEM and TG. The hydrogel's compressive strength, equilibrium swelling and bacteriostatic efficiency were systematically studied. The research results showed that the maximum equilibrium swelling rate of hydrogel was 720%, the maximum compressive strength was 1500 Pa, and could self-heal within 12 h. In addition, the hydrogel could effectively inhibit E. coli and S. aureus, and also showed a good release behavior for bovine serum albumin (BSA). The CCK-8 method proved that the hydrogel was non-toxic to murine fibroblasts and could promote cell proliferation and growth to a certain extent. This research has potential significance for the application of self-healing hydrogel materials in the field of biomedicine.

建立了一种利用O-壳聚糖季铵盐( O -HACC)、聚乙烯醇(PVA)和氧化石墨烯(GO)制备O -HACC/PVA/GO双重自修复抑菌水凝胶的简便方法。^{然后通过FT-IR、X-RD、 1} H NMR、SEM和TG对水凝胶和材料进行了表征。系统研究了水凝胶的抗压强度、平衡膨胀和抑菌效率。研究结果表明，水凝胶的最大平衡溶胀率为720%，最大抗压强度为1500 Pa，并能在12 h内自愈。此外，该水凝胶可有效抑制大肠杆菌和金黄色葡萄球菌。, 并且对牛血清白蛋白 (BSA) 也表现出良好的释放行为。CCK-8法证明该水凝胶对小鼠成纤维细胞无毒，可在一定程度上促进细胞增殖和生长。该研究对自愈水凝胶材料在生物医学领域的应用具有潜在意义。