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A Scattering Nanopore for Single Nanoentity Sensing
ACS Sensors ( IF 8.2 ) Pub Date : 2016-08-26 00:00:00 , DOI: 10.1021/acssensors.6b00408
Xin Shi 1 , Rui Gao 1 , Yi-Lun Ying 1 , Wei Si 2 , Yun-Fei Chen 2 , Yi-Tao Long 1
ACS Sensors ( IF 8.2 ) Pub Date : 2016-08-26 00:00:00 , DOI: 10.1021/acssensors.6b00408
Xin Shi 1 , Rui Gao 1 , Yi-Lun Ying 1 , Wei Si 2 , Yun-Fei Chen 2 , Yi-Tao Long 1
Affiliation
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Optical nanopore methods are widely believed to be practical approaches to address the flicker noise and the throughput limitations of nanopore detection. However, most optical nanopore methods in the literature are based on fluorescent labeling, which perplexes the detection operation and limits their applications. In this paper, we demonstrate a brand new optical nanopore technique named “scattering nanopore method”. This method achieves single nanopore readouts without the introduction of dyes by detecting scattering light through a single subwavelength aperture on Au film. The single particle induced optical fluctuations could be detected simultaneously with the nanopore ionic current readouts. The method we demonstrated here opens a new direction for nanopore sensing of single particles, even single molecules in the near future.
中文翻译:
单一纳米实体感测的散射纳米孔。
人们普遍认为,光学纳米孔方法是解决闪烁噪声和纳米孔检测通量限制的实用方法。然而,文献中大多数光学纳米孔方法基于荧光标记,这使检测操作复杂化并限制了它们的应用。在本文中,我们演示了一种名为“散射纳米孔法”的全新光学纳米孔技术。该方法通过检测穿过Au膜上单个亚波长孔的散射光,实现了单个纳米孔的读出而无需引入染料。可以与纳米孔离子电流读数同时检测单个粒子引起的光学波动。我们在此展示的方法为在不久的将来甚至是单个分子的纳米孔传感开辟了新的方向。
更新日期:2016-08-26
中文翻译:
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单一纳米实体感测的散射纳米孔。
人们普遍认为,光学纳米孔方法是解决闪烁噪声和纳米孔检测通量限制的实用方法。然而,文献中大多数光学纳米孔方法基于荧光标记,这使检测操作复杂化并限制了它们的应用。在本文中,我们演示了一种名为“散射纳米孔法”的全新光学纳米孔技术。该方法通过检测穿过Au膜上单个亚波长孔的散射光,实现了单个纳米孔的读出而无需引入染料。可以与纳米孔离子电流读数同时检测单个粒子引起的光学波动。我们在此展示的方法为在不久的将来甚至是单个分子的纳米孔传感开辟了新的方向。