In this study, copper mine tailings were used as a replacement for Portland cement in concrete construction using sintering process. The applicability of the concrete samples was evaluated through TG, DTA, SEM, FTIR, XRD, and TCLP. The 28-day compressive strength of the concrete sample made of cement-substituted copper tailings was 42 MPa, which was 9% lower than that of the control sample. It was well supported using t-test with the p-value < 0.05. The TG and DTA tests results indicated that despite the presence of different compounds in the cement samples, the peaks of these tests were almost the same. The TCLP test results showed that the amount of studied heavy metals leaching in all concrete samples was lower than the standard limit (p-values less than 0.05). According to XRD and FTIR results, cement hydration process was well performed, and tricalcium silicate (alite) and dicalcium silicate (belite) phases were formed in the manufactured cement samples. In general, cement clinkers produced using Sungun copper mine tailings could be considered as a substitute for Portland cement in concrete construction.