Objective: 

This study aimed to investigate the relationships between sleep apnea parameters and various symptoms in postmenopausal women who had treatment-resistant sleep disorders.

Methods: 

The respiratory disturbance index (RDI), the number of times apnea-hypopnea occurred in an hour, and transcutaneous oxygen saturation (SpO₂) were monitored during one night of sleep using a portable monitoring device in 51 postmenopausal women who did not have an improved subjective sleep quality with the use of hypnotics. Physical and psychological health statuses and subjective sleep disturbance were evaluated using validated questionnaires, including the Epworth Sleepiness Scale, the Cornell Medical Index, and the Questionnaire for Assessment of Climacteric Syndrome in Japanese Women. The associations between RDI, nadir SpO₂ and various symptoms, as well as cardiovascular parameters, such as blood pressure, serum lipid profile, and glucose tolerance, were analyzed separately.

Results: 

Among the 51 study participants, seven (13.7%) were diagnosed with obstructive sleep apnea. After adjustment for age, body mass index, and the background factors related to RDI and nadir SpO2, the association remained significant between a higher RDI and joint pain (Questionnaire for Assessment of Climacteric Syndrome in Japanese Women) (standardized partial regression coefficient [β] = 0.423, P= 0.016), and between lower nadir SpO₂ and fatigability (Cornell Medical Index) (β = –0.472, P= 0.007).

Conclusions: 

Detailed examination of sleep-disordered breathing is warranted in women with severe joint pain and fatigability.

中文翻译：

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绝经后妇女的睡眠呼吸暂停与关节疼痛的严重程度和易疲劳性有关：一项横断面研究

客观的： 

本研究旨在调查患有难治性睡眠障碍的绝经后妇女的睡眠呼吸暂停参数与各种症状之间的关系。

方法： 

使用便携式监测设备对 51 名没有改善的绝经后妇女的一晚睡眠期间的呼吸障碍指数 (RDI)、一小时内发生呼吸暂停-低通气的次数和经皮血氧饱和度 (SpO ₂ ) 进行监测使用催眠药的主观睡眠质量。使用经过验证的问卷评估身体和心理健康状况以及主观睡眠障碍，包括 Epworth 嗜睡量表、康奈尔医学指数和日本女性更年期综合症评估问卷。分别分析了 RDI、最低点 SpO ₂与各种症状以及心血管参数（如血压、血脂谱和葡萄糖耐量）之间的关联。

结果： 

在 51 名研究参与者中，7 名 (13.7%) 被诊断出患有阻塞性睡眠呼吸暂停。在调整了年龄、体重指数以及与 RDI 和最低点 SpO2 相关的背景因素后，较高的 RDI 与关节疼痛之间的关联仍然显着（日本女性更年期综合征评估问卷）（标准化偏回归系数 [β] = 0.423，P = 0.016），以及在较低的最低点 SpO ₂和疲劳性（康奈尔医学指数）之间（β = –0.472，P = 0.007）。

结论： 

对于患有严重关节疼痛和易疲劳的女性，需要对睡眠呼吸障碍进行详细检查。