Abstract

A series of novel 3,4,5-trimethoxycinnamamide-tethered 1,2,3-triazole derivatives were prepared by the click reaction of (E)-N-(prop-2-yn-1-yl)-3-(3,4,5-trimethoxyphenyl) acrylamide with different aryl azides. The synthesized compounds were characterized by ¹H and ¹³C NMR and mass spectra and elemental analyses and were screened for their in vitro anticancer activity against MCF-7 and A549 cell lines by using MTT assay. Most of the tested compounds showed prominent activity against both cancer cell lines.

中文翻译：

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3,4,5-三甲氧基肉桂酰胺-栓系1,2,3-三唑衍生物的合成及抗癌活性

摘要

( E ) -N- (prop-2-yn-1-yl)-3-(3 ,4,5-三甲氧基苯基）丙烯酰胺与不同的芳基叠氮化物。合成的化合物通过¹ H 和¹³ C NMR 以及质谱和元素分析进行​​表征，并通过 MTT 法筛选它们对 MCF-7 和 A549 细胞系的体外抗癌活性。大多数测试的化合物对两种癌细胞系都显示出显着的活性。