房角闭合程度、眼前节尺寸和眼压,British Journal of Ophthalmology

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房角闭合程度、眼前节尺寸和眼压
British Journal of Ophthalmology ( IF 3.7 ) Pub Date : 2023-07-01 , DOI: 10.1136/bjophthalmol-2021-320453
Natalia Porporato _{1,

2} , Rachel Chong _{1,

2} , Benjamin Y Xu ₃ , Tin A Tun _{1,

2} , Joanne HuiMin Quah ₄ , Marcus Tan ₅ , Mani Baskaran ₁ , Ching Yu Cheng _{1,

2} , Tin Aung _{2,

6,

7}

Affiliation

目的研究通过扫源光学相干断层扫描（SS-OCT；CASIA SS-1000，Tomey，名古屋，日本）测量的虹膜小梁接触程度和其他定量眼前节尺寸与眼压 (IOP) 之间的关联。方法横断面研究。所有年龄≥50岁且无青光眼、眼科手术或外伤史的受试者均在同一天接受了SS-OCT成像（八次等距径向扫描）、Goldman压平眼压测量和前房角镜检查。我们测量了虹膜小梁接触 (ITC) 指数和面积、小梁虹膜间隙总体积以及距巩膜刺 500 和 750 处的开角距离（分别为 TISA 500 和 750，AOD 500 和 750）、前房深度 (ACD) ）、体积、面积和宽度、瞳孔直径、晶状体穹窿和虹膜体积。它们与 IOP（因变量）的关系通过局部加权散点图平滑 (Lowess) 回归、变点分析和针对混杂因素调整的广义加性模型进行评估。结果对 2027 名新加坡华人 (90%) 的右眼进行了分析。ITC 指数高于约 60% 的阈值（95% CI 34% 至 92%）与较高的 IOP 显着相关。与 ITC 的范围无关，ACD 还与低于 2.5 mm 阈值的较高 IOP 显着相关（95% CI 2.33 mm 至 2.71 mm）。较大的 ITC 指数和较浅的 ACD 与 IOP 具有联合关联。包含 ACD 和 ITC 指数的模型比单独考虑这些变量的模型更能预测 IOP，特别是对于房角镜闭角的女性（R2 52.7%，p<0.05）。结论房角闭合程度和 ACD 低于某一阈值与 IOP 具有显着的联合相关性。这些参数作为房水流出机械阻塞的生物特征替代物，可能共同导致眼压升高，特别是在房角镜闭角的女性中。可根据合理要求提供数据。数据可根据要求提供。

"点击查看英文标题和摘要"

Angle closure extent, anterior segment dimensions and intraocular pressure

Aim To investigate the association between the extent of iridotrabecular contact and other quantitative anterior segment dimensions measured by swept-source optical coherence tomography (SS-OCT; CASIA SS-1000, Tomey, Nagoya, Japan) with intraocular pressure (IOP). Methods Cross-sectional study. All subjects who were ≥50 years with no history of glaucoma, ocular surgery or trauma, underwent SS-OCT imaging (eight equally spaced radial scans), Goldman applanation tonometry and gonioscopy on the same day. We measured iridotrabecular contact (ITC) index and area, total volume of trabeculo-iris space area and angle opening distance at 500 and 750 from the scleral spur (TISA 500 and 750, AOD 500 and 750, respectively), anterior chamber depth (ACD), volume, area and width, pupil diameter, lens vault and iris volume.Their relationship with IOP (dependent variable) was assessed by locally weighted scatterplot smoothing (Lowess) regression with change-point analysis and generalised additive models adjusted for confounders. Results 2027 right eyes of mostly Chinese Singaporeans (90%) were analysed. ITC index above a threshold of ~60% (95% CI 34% to 92%) was significantly associated with higher IOP. Independent of the extent of ITC, ACD was also significantly associated with higher IOP below a threshold of 2.5 mm (95% CI 2.33 mm to 2.71 mm). Greater ITC index and shallower ACD had a joint association with IOP. A model including ACD and ITC index was more predictive of IOP than a model considering these variables separately, particularly for women with gonioscopically closed angles (R2 52.7%, p<0.05). Conclusions The extent of angle closure and the ACD below a certain threshold had a significant joint association with IOP. These parameters, as biometrical surrogates of mechanical obstruction of the aqueous outflow, may jointly contribute to elevated IOP, particularly in women with gonioscopic angle closure. Data are available on reasonable request. Data are available upon request.

更新日期：2023-06-22

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