不同的肝脏免疫模式与肝细胞癌的进展或抑制有关,Cell Reports

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不同的肝脏免疫模式与肝细胞癌的进展或抑制有关
Cell Reports ( IF 7.5 ) Pub Date : 2022-03-01 , DOI: 10.1016/j.celrep.2022.110454
Faridoddin Mirshahi ₁ , Hussein F Aqbi ₂ , Madison Isbell ₃ , Saeed H Manjili ₁ , Chunqing Guo ₄ , Mulugeta Saneshaw ₅ , Dipankar Bandyopadhyay ₆ , Mikhail Dozmorov ₆ , Archit Khosla ₇ , Katy Wack ₇ , Oscar M Carrasco-Zevallos ₇ , Michael O Idowu ₈ , Xiang-Yang Wang ₉ , Arun J Sanyal ₁₀ , Masoud H Manjili ₁₁

Affiliation

Department of Internal Medicine, VCU School of Medicine, Richmond, VA 23298, USA.
Department of Internal Medicine, VCU School of Medicine, Richmond, VA 23298, USA; VCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA; College of Science, Mustansiriyah University, Baghdad, Iraq.
Department of Microbiology & Immunology, VCU School of Medicine, Richmond, VA 23298, USA.
Department of Human & Molecular Genetics, VCU School of Medicine, Richmond, VA 23298, USA.
VCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA.
VCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA; Department of Biostatistics, Virginia Commonwealth University, Richmond, VA 23298, USA.
PathAI, Inc., Boston, MA 02215, USA.
VCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA; Department of Pathology, VCU School of Medicine, Richmond, VA 23298, USA.
VCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA; Department of Human & Molecular Genetics, VCU School of Medicine, Richmond, VA 23298, USA; Hunter Holmes McGuire VA Medical Center, Richmond, VA 23298, USA.
Department of Internal Medicine, VCU School of Medicine, Richmond, VA 23298, USA; VCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA.
Department of Microbiology & Immunology, VCU School of Medicine, Richmond, VA 23298, USA; VCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA; Department of Pathology, VCU School of Medicine, Richmond, VA 23298, USA.

为了发现促进或抑制肝细胞癌 (HCC) 的不同免疫反应，我们对免疫细胞进行了三维分析，将免疫细胞类型、相互作用和随时间变化的动物模型关联起来，显示非酒精性脂肪肝疾病的性别差异。 NAFLD) 相关的 HCC。作为对西方饮食 (WD) 的反应，动物分别产生急性和慢性炎症细胞因子模式。男性和女性的肿瘤进展与肝脏中主要的 CD8 ^{+ >} CD4 ⁺、Th1 > Th17 > Th2、NKT > NK、M1 > M2 模式相关。从 HCC 中完全拯救女性与平衡 Th1 = Th17 = Th2、NKT = NK、M1 = M2 模式相关，而从 HCC 中部分拯救男性与平衡 CD8 相关⁺ = CD4 ⁺ , NKT = NK 和半平衡 Th1 = Th17 > Th2 但肝脏中持续的 M1 > M2 模式。我们的数据表明，免疫模式识别可以解释 HCC 的免疫生物学，并指导免疫调节干预以特定性别的方式治疗 HCC。

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更新日期：2022-03-01

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