Recent advances in the applications of pyrazolone derivatives in enantioselective synthesis,Organic & Biomolecular Chemistry

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Recent advances in the applications of pyrazolone derivatives in enantioselective synthesis
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2022-02-20 , DOI: 10.1039/d1ob02426d
Xiaoze Bao ₁ , Xingyue Wang ₁ , Jin-Miao Tian ₁ , Xinyi Ye ₁ , Baomin Wang ₂ , Hong Wang ₁

Affiliation

Pyrazolones and pyrazoles, featuring nitrogen–nitrogen bonds, are two of the most important classes of heterocycles, owing to their widespread occurrence in medicinal chemistry and functional materials. The last decade has witnessed a rapid increase in the construction of chiral pyrazolone and pyrazole derivatives, with the application of pyrazolone derivatives as powerful synthons. Since our last review in 2018, a large number of new achievements has emerged in this area, requiring a timely update. Thus, this review summarizes these elegant achievements based on the multiple reactive sites of different pyrazolone synthons. In addition, important mechanisms and interesting biological investigations relating to the corresponding products are also discussed.

中文翻译：

吡唑啉酮衍生物在对映选择性合成中的应用研究进展

吡唑酮和吡唑具有氮-氮键，是最重要的两类杂环化合物，因为它们广泛存在于药物化学和功能材料中。过去十年见证了手性吡唑酮和吡唑衍生物的构建迅速增加，吡唑酮衍生物作为强大的合成子应用。自 2018 年上一次审查以来，该领域涌现了大量新成果，需要及时更新。因此，本综述基于不同吡唑酮合成子的多个反应位点总结了这些出色的成就。此外，还讨论了与相应产品相关的重要机制和有趣的生物学研究。

更新日期：2022-02-20

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