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Enzyme-responsive strategy as a prospective cue to construct intelligent biomaterials for disease diagnosis and therapy
Biomaterials Science ( IF 5.8 ) Pub Date : 2022-02-27 , DOI: 10.1039/d2bm00067a
Meiyu Wang 1 , Bin Gao 1 , Xiaoyu Wang 1 , Wenzhong Li 2 , Yakai Feng 1, 3, 4
Affiliation  

Stimulus-responsive materials have been widely studied and applied in biomedical fields. Under the stimulation of enzymes, enzyme-responsive materials (ERMs) can be triggered to change their structures, properties and functions. Herein, natural enzymes act as the endogenous trigger. Owing to the specificity of natural enzymes, ERMs can exert functions in the specific tissues containing these enzymes, while remaining inert in other tissues. This is beneficial for modulating the therapy efficacy and alleviating systemic or local toxicities in vivo when ERMs are used to deliver therapeutic molecules. This article focuses on introducing enzyme-responsive strategies, ERMs and their applications in cancer and cardiovascular disease diagnosis, therapy and theranostics. Enzyme-responsive strategies provide a promising research cue to construct intelligent biomaterials for disease treatment and diagnosis.

中文翻译:

酶响应策略作为构建用于疾病诊断和治疗的智能生物材料的前瞻性线索

刺激响应材料在生物医学领域得到了广泛的研究和应用。在酶的刺激下,可以触发酶响应材料(ERM)改变其结构、性质和功能。在此,天然酶充当内源性触发器。由于天然酶的特异性,ERMs 可以在含有这些酶的特定组织中发挥作用,而在其他组织中保持惰性。这有利于调节治疗效果并减轻体内全身或局部毒性当 ERM 用于传递治疗分子时。本文重点介绍酶反应策略、ERM 及其在癌症和心血管疾病诊断、治疗和治疗学中的应用。酶响应策略为构建用于疾病治疗和诊断的智能生物材料提供了有希望的研究线索。
更新日期:2022-02-27
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