Selective binding of ReO4– And PtCl42– By a Pd2L4 cage in water,Inorganic Chemistry Communications

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Selective binding of ReO4– And PtCl42– By a Pd2L4 cage in water
Inorganic Chemistry Communications ( IF 4.4 ) Pub Date : 2022-02-26 , DOI: 10.1016/j.inoche.2022.109284
Xander Schaapkens ₁ , Joost N.H. Reek ₁ , Tiddo J. Mooibroek ₁

Affiliation

Anions such as pertechnetate (TcO) and tetrachloroplatinate (PtCl) are important precursors for radioactive substances for medical imaging. Molecules that can sense and bind these small anions in water can be exploited to circumvent lengthy synthesis on radioactive material and improve these applications. The most important property of a host is its selectivity for non-biological anions over common biological anions and/or molecules. Here, we report that a previous published [PdL] guanidinium cage has higher selectivity for ReO and particularly for PtCl (nonradioactive substitutes for TcO and PtCl) over common biological molecules. This selectivity was shown by means of H NMR titrations with the most noticeable affinity for PtCl in the order of = 10 M. A molecular model of PtCl or ReO bound inside the cage revealed the best interaction complementary fit with the PtCl anion, which is held in place by equally short N–H···Cl and C–H···Cl hydrogen bonds. This research shows that a simple coordination cage can already have selective binding for non-biological anions such as ReO and particularly for PtCl, paving the way to improve coordination cages for use in medical imaging research.

中文翻译：

ReO4– 和 PtCl42– 通过水中的 Pd2L4 笼选择性结合

高锝酸根 (TcO) 和四氯铂酸根 (PtCl) 等阴离子是医学成像放射性物质的重要前体。可以利用能够感知和结合水中这些小阴离子的分子来避免放射性材料的漫长合成并改善这些应用。宿主最重要的特性是其对非生物阴离子相对于常见生物阴离子和/或分子的选择性。在这里，我们报告说，之前发表的 [PdL] 胍笼对 ReO，特别是 PtCl（TcO 和 PtCl 的非放射性替代品）比常见的生物分子具有更高的选择性。这种选择性通过 H NMR 滴定显示，对 PtCl 的亲和力最显着，约为 10 M。结合在笼内的 PtCl 或 ReO 的分子模型揭示了与 PtCl 阴离子的最佳相互作用互补拟合，这被认为是由同样短的 N–H·Cl 和 C–H·Cl 氢键组成。这项研究表明，简单的配位笼已经可以选择性结合 ReO 等非生物阴离子，特别是 PtCl，为改进配位笼在医学成像研究中的应用铺平了道路。

更新日期：2022-02-26

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