Photo-Reduction with NIR Light of Nucleus-Targeting PtIV Nanoparticles for Combined Tumor-Targeted Chemotherapy and Photodynamic Immunotherapy,Angewandte Chemie International Edition

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Photo-Reduction with NIR Light of Nucleus-Targeting PtIV Nanoparticles for Combined Tumor-Targeted Chemotherapy and Photodynamic Immunotherapy
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-02-25 , DOI: 10.1002/anie.202201486
Dengshuai Wei _{1,

2} , Yun Huang ₁ , Bin Wang _{1,

2} , Lili Ma ₃ , Johannes Karges ₄ , Haihua Xiao _{1,

2}

Affiliation

The example of Pt^IV nanoparticles that could be excited within the NIR region at 808 nm is reported. The complex was functionalized with a photosensitizer for photodynamic therapy and nucleus/cancer-targeting peptides which self-assemble into nanoparticles. Upon irradiation, the Pt^IV center is reduced to Pt^II, presenting a multimodal treatment by chemotherapy and photodynamic immunotherapy.

中文翻译：

近红外光还原核靶向 PtIV 纳米颗粒用于肿瘤靶向化疗和光动力免疫治疗的联合治疗

报道了可以在 808 nm 的 NIR 区域内激发的 Pt ^{IV纳米粒子的例子。}该复合物用用于光动力治疗的光敏剂和自组装成纳米颗粒的核/癌症靶向肽进行功能化。照射后，Pt ^IV中心减少为 Pt ^II，呈现通过化学疗法和光动力免疫疗法的多模式治疗。

更新日期：2022-02-25

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