This review is written to endow updated information on polypyrrole based photosensitizers for the treatment of deadly diseases such as cancer and microbial infection. Tetrapyrrolic macromolecules such as porphyrins and phthalocyanines hold unique photophysical properties which make them very useful compounds for various biomedical applications. Besides their properties, they also have some limitations such as low water solubility, bioavailability, biocompatibility and lack of specificity, etc. Researchers are trying to overcome these limitations by incorporating photosensitizers into the different types of nanoparticles and improve the quality of photodynamic therapy. We have contributed to this field by synthesizing and developing polypyrrolic photosensitizer based nanoparticles for potential applications in antimicrobial and anticancer photodynamic activity. Throughout this review, newly synthesized and existing PSs conjugated/encapsulated/doped/incorporated with nanoparticles are emphasized, which are essential for current and future research themes. Also in this review, we briefly summarized the research work carried over the past few years by considering the porphyrin based photosensitizers as alternative therapeutic entities for the treatment of microbial infections, cancers, and many other diseases.

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基于聚吡咯的光动力疗法纳米制剂的见解

这篇综述旨在提供有关基于聚吡咯的光敏剂治疗癌症和微生物感染等致命疾病的最新信息。卟啉和酞菁等四吡咯大分子具有独特的光物理特性，使其成为各种生物医学应用中非常有用的化合物。除了它们的特性外，它们还具有一些局限性，例如低水溶性、生物利用度、生物相容性和缺乏特异性，等等. 研究人员正试图通过将光敏剂加入不同类型的纳米粒子中来克服这些限制，并提高光动力治疗的质量。我们通过合成和开发基于聚吡咯光敏剂的纳米粒子在抗菌和抗癌光动力学活性中的潜在应用为该领域做出了贡献。在这篇综述中，强调了新合成的和现有的与纳米粒子共轭/封装/掺杂/掺入的 PS，这对于当前和未来的研究主题至关重要。同样在这篇综述中，我们简要总结了过去几年的研究工作，将基于卟啉的光敏剂视为治疗微生物感染、癌症和许多其他疾病的替代治疗实体。