Rapid Access to Multisubstituted Acrylamides from Cyclic Ketones via Palladium/Norbornene Cooperative Catalysis,Angewandte Chemie International Edition

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Rapid Access to Multisubstituted Acrylamides from Cyclic Ketones via Palladium/Norbornene Cooperative Catalysis
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-02-23 , DOI: 10.1002/anie.202201239
Zhao Wu ₁ , Guangbin Dong ₁

Affiliation

A palladium/norbornene-catalyzed vicinal difunctionalization of enol triflates has been developed for rapid, modular and regioselective synthesis of multisubstituted acrylamides from simple ketones. The reaction exhibits broad functional group tolerance, and the use of bulky secondary amide-derived norbornenes appears to be a key parameter to maintain high efficiency and selectivity.

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