Polypropylene (PP) mesh has been one of the most frequently selected materials for abdominal wall hernia (AWH) repair in the past decades. However, the repair effectiveness is often compromised by the high incidence of adverse events. Improvements are highly desirable to reduce unwanted visceral adhesion and increase tissue integration. Herein, we developed a PP-based composite mesh combined with alginate-assistant nanofiber membrane (NFM) by assembling a large-pore lightweight PP mesh, a NFM barrier consisting of poly (lactic-co-glycolic acid) (PLGA) and polycaprolactone (PCL), and an alginate hydrogel (AH). In vitro studies revealed that the resulting meshes had excellent structural stability, mechanical properties, and biocompatibility. The NFM barriers were firmly attached to the PP substrates, with AH effectively eliminating the delamination without unwanted damage to the nanofiber barrier. In vivo experiments showed that incorporating AH-assistant NFM into PP prostheses could prevent visceral adhesion in an effective manner and promote mesh integration into surrounding tissues from the abdominal wall. These results prove a novel facile and successful strategy to endow prosthetic meshes with superior anti-adhesion capability and tissue compatibility for repairing AWH.

在过去的几十年中，聚丙烯 (PP) 网片一直是腹壁疝 (AWH) 修复最常用的材料之一。然而，修复效果通常会因不良事件的高发生率而受到影响。非常需要改进以减少不需要的内脏粘连和增加组织整合。在此，我们通过组装大孔轻质 PP 网格、由聚乳酸-乙醇酸共聚物 (PLGA) 和聚己内酯组成的 NFM 屏障，开发了一种与藻酸盐辅助纳米纤维膜 (NFM) 相结合的 PP 基复合网格。 PCL) 和藻酸盐水凝胶 (AH)。体外研究表明，所得网格具有出色的结构稳定性、机械性能和生物相容性。NFM 屏障牢固地附着在 PP 基材上，AH 有效地消除了分层，而不会对纳米纤维屏障造成不必要的损坏。体内实验表明，在 PP 假体中加入 AH 辅助 NFM 可以有效地防止内脏粘连，并促进网片从腹壁融入周围组织。这些结果证明了一种新的简便且成功的策略，可以赋予假体网以优异的抗粘连能力和组织相容性来修复 AWH。