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Sustainable Antibacterial and Anti-Inflammatory Silk Suture with Surface Modification of Combined-Therapy Drugs for Surgical Site Infection
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2022-02-22 , DOI: 10.1021/acsami.2c00106 Xuchen Wang 1 , Peixin Liu 2, 3 , Qinting Wu 1 , Zhaozhu Zheng 1 , Maobin Xie 4 , Guoqiang Chen 1 , Jia Yu 2, 3 , Xiaoqin Wang 1 , Gang Li 1 , David Kaplan 5
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2022-02-22 , DOI: 10.1021/acsami.2c00106 Xuchen Wang 1 , Peixin Liu 2, 3 , Qinting Wu 1 , Zhaozhu Zheng 1 , Maobin Xie 4 , Guoqiang Chen 1 , Jia Yu 2, 3 , Xiaoqin Wang 1 , Gang Li 1 , David Kaplan 5
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Silk sutures with antibacterial and anti-inflammatory functions were developed for sustained dual-drug delivery to prevent surgical site infections (SSIs). The silk sutures were prepared with core–shell structures braided from degummed silk filaments and then coated with a silk fibroin (SF) layer loaded with berberine (BB) and artemisinin (ART). Both the rapid release of drugs to prevent initial biofilm formation and the following sustained release to maintain effective concentrations for more than 42 days were demonstrated. In vitro assays using human fibroblasts (Hs 865.Sk) demonstrated cell proliferation on the materials, and hemolysis was 2.4 ± 0.8%, lower than that required by ISO 10993-4 standard. The sutures inhibited platelet adhesion and promoted collagen deposition and blood vessel formation. In vivo assessments using Sprague–Dawley (SD) rats indicated that the coating reduced the expression of pro-inflammatory cytokines interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α), shortening the inflammatory period and promoting angiogenesis. The results demonstrated that these new sutures exhibited stable structures, favorable biocompatibility, and sustainable antibacterial and anti-inflammatory functions with potential for surgical applications.
中文翻译：
具有联合治疗药物表面修饰的可持续抗菌抗炎丝线缝合线用于治疗手术部位感染
开发了具有抗菌和抗炎功能的丝线，用于持续双药输送，以防止手术部位感染（SSI）。丝缝合线由脱胶丝丝编织而成的核壳结构制成，然后涂有负载小檗碱（BB）和青蒿素（ART）的丝素蛋白（SF）层。药物快速释放以防止初始生物膜形成，以及随后的持续释放以维持有效浓度超过 42 天，均得到证实。使用人成纤维细胞（Hs 865.Sk）的体外测定表明材料上的细胞增殖，溶血率为2.4±0.8%，低于ISO 10993-4标准要求。缝合线抑制血小板粘附并促进胶原沉积和血管形成。使用 Sprague-Dawley (SD) 大鼠进行的体内评估表明，涂层降低了促炎细胞因子白介素-10 (IL-10) 和肿瘤坏死因子-α (TNF-α) 的表达，缩短了炎症周期并促进血管生成。结果表明，这些新型缝线具有稳定的结构、良好的生物相容性和可持续的抗菌和抗炎功能，具有外科应用的潜力。
更新日期：2022-02-22
中文翻译：
具有联合治疗药物表面修饰的可持续抗菌抗炎丝线缝合线用于治疗手术部位感染
开发了具有抗菌和抗炎功能的丝线，用于持续双药输送，以防止手术部位感染（SSI）。丝缝合线由脱胶丝丝编织而成的核壳结构制成，然后涂有负载小檗碱（BB）和青蒿素（ART）的丝素蛋白（SF）层。药物快速释放以防止初始生物膜形成，以及随后的持续释放以维持有效浓度超过 42 天，均得到证实。使用人成纤维细胞（Hs 865.Sk）的体外测定表明材料上的细胞增殖，溶血率为2.4±0.8%，低于ISO 10993-4标准要求。缝合线抑制血小板粘附并促进胶原沉积和血管形成。使用 Sprague-Dawley (SD) 大鼠进行的体内评估表明，涂层降低了促炎细胞因子白介素-10 (IL-10) 和肿瘤坏死因子-α (TNF-α) 的表达，缩短了炎症周期并促进血管生成。结果表明，这些新型缝线具有稳定的结构、良好的生物相容性和可持续的抗菌和抗炎功能，具有外科应用的潜力。
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