Comprehensive evaluation of chiral pydiflumetofen from the perspective of reducing environmental risks,Science of the Total Environment

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Comprehensive evaluation of chiral pydiflumetofen from the perspective of reducing environmental risks
Science of the Total Environment ( IF 8.2 ) Pub Date : 2022-02-19 , DOI: 10.1016/j.scitotenv.2022.154033
Shanshan Di ₁ , Tao Cang ₁ , Zhenzhen Liu ₁ , Yunye Xie ₂ , Huiyu Zhao ₁ , Peipei Qi ₁ , Zhiwei Wang ₁ , Hao Xu ₁ , Xinquan Wang ₁

Affiliation

The spatial structures of chiral pesticide enantiomers can affect their activity, toxicity and behavior, thereby altering exposure risk. Identifying enantiomer differences and developing high-efficiency green enantiopure pesticide is an important strategy for reducing the negative effects of pesticides. In this study, after confirming the absolute configuration of pydiflumetofen enantiomers, fungicidal activity evaluation indicated that the activity of S-(+)-pydiflumetofen was 81.3–421 times higher than R-(−)-pydiflumetofen on three kinds of phytopathogens that control Fusarium wilt (Fusarium spp.), Alternaria rot (Alternaria alternata) and Southern blight (Sclerotinia rolfsii), which might be caused by the stronger binding ability of S-(+)-pydiflumetofen with the active site of the target protein. The coexistence of R-(−)-pydiflumetofen would enhance the toxicity of S-(+)-pydiflumetofen on zebrafish through synergistic effect. Low-activity R-(−)-pydiflumetofen was preferentially dissipated in soybean, soybean plants, cabbage and celery, which was opposite in soil. The persistence of S-(+)-pydiflumetofen in crops and degradability in soil were advantageous for pesticide effects and environmental protection. Based on the maximum residue limit (MRL) and hazard quotient (HQ), the dietary risks were determined to be acceptable for all crops. Thus, developing enantiopure S-(+)-pydiflumetofen products might be a high-efficiency and low-risk strategy, and more studies should be conducted in this aspect.

中文翻译：

从降低环境风险的角度看手性吡啶氟酯的综合评价

手性农药对映异构体的空间结构会影响其活性、毒性和行为，从而改变暴露风险。识别对映异构体差异并开发高效的绿色对映体纯农药是减少杀虫剂负面影响的重要策略。在本研究中，在确认了 pydiflumetofen 对映异构体的绝对构型后，杀菌活性评价表明，S-（+）-pydiflumetofen 对控制镰刀菌枯萎病（Fusarium spp.）、链格孢菌腐病（Alternaria alternata）和南方枯萎病（Sclerotinia rolfsii）的三种植物病原体的活性比 R-（−）-pydiflumetofen 高 81.3–421 倍，这可能是由于 S-（+）-pydiflumetofen 与靶标活性位点的结合能力更强所致蛋白。R-（−）-pydiflumetofen 的共存会通过协同效应增强 S-（+）-pydiflumetofen 对斑马鱼的毒性。低活性 R-（−）-pydiflumetofen 优先消散在大豆、大豆植株、卷心菜和芹菜中，这在土壤中则相反。S-（+）-吡啶氟虫草芬在作物中的持久性和在土壤中的降解性有利于农药效果和环境保护。根据最大残留限量（MRL）和危害商（HQ），确定所有作物的饮食风险都是可接受的。因此，开发对映体纯 S-（+）-吡二氟酯产品可能是一种高效、低风险的策略，应在这方面进行更多研究。

更新日期：2022-02-19

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