Short Guanidinium-Functionalized Poly(2-oxazoline)s Displaying Potent Therapeutic Efficacy on Drug-Resistant Fungal Infections,Angewandte Chemie International Edition

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Short Guanidinium-Functionalized Poly(2-oxazoline)s Displaying Potent Therapeutic Efficacy on Drug-Resistant Fungal Infections
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-02-19 , DOI: 10.1002/anie.202200778
Weinan Jiang ₁ , Min Zhou ₁ , Zihao Cong _{2,

3} , Jiayang Xie _{2,

3} , Wenjing Zhang _{2,

3} , Sheng Chen _{2,

3} , Jingcheng Zou _{2,

3} , Zhemin Ji _{2,

3} , Ning Shao _{2,

3} , Xin Chen ₃ , Maoquan Li ₄ , Runhui Liu _{1,

2,

3}

Affiliation

Inspired by cell-penetrating peptides, guanidinium-pendent poly(2-oxazoline)s were designed as synthetic mimics of host defense peptides to display potent antifungal properties, owing to the enhanced penetrating efficiency into fungal cells. Short guanidinium-pendent poly(2-oxazoline)s display strong therapeutic potential as a class of promising antifungal agents.

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