具有抗氧化功能的生物陶瓷支架用于 ROS 清除和骨软骨再生,Advanced Science

当前位置： X-MOL 学术 › Adv. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

具有抗氧化功能的生物陶瓷支架用于 ROS 清除和骨软骨再生
Advanced Science ( IF 14.3 ) Pub Date : 2022-02-19 , DOI: 10.1002/advs.202105727
Cuijun Deng _{1,

2,

3} , Quan Zhou _{1,

2} , Meng Zhang ₂ , Tian Li ₂ , Haotian Chen _{1,

3} , Chang Xu ₁ , Qishuai Feng ₁ , Xin Wang ₂ , Feng Yin ₃ , Yu Cheng ₁ , Chengtie Wu ₂

Affiliation

骨关节炎（OA）是一种退行性疾病，涉及过量的活性氧（ROS）和骨软骨缺损。尽管已经开发了多种用于骨软骨再生的方法，但如何平衡 OA 中的生化和物理微环境仍然是一个巨大的挑战。在这项研究中，开发了一种由 3D 打印的akermanite (AKT) 与毛发衍生的抗氧化纳米颗粒 (HNPs)/微粒 (HMPs) 相结合的生物陶瓷支架，用于 ROS 清除和骨软骨再生。制备的具有多模拟酶作用的生物支架可广泛清除OA中的自由基，在ROS微环境下保护软骨细胞。重要的，由于通过 HNPs/HMPs 刺激葡萄糖转运通路 (GLUT)，生物支架可以明显刺激软骨细胞的增殖和成熟。此外，它显着加速了骨髓间充质干细胞（BMSCs）的成骨分化。体内结果表明，与未修饰的支架相比，生物支架可以有效地促进骨软骨再生。该工作表明，通过生物支架整合抗氧化和机械性能是 OA 治疗中骨软骨再生的一种有前景的策略。

"点击查看英文标题和摘要"

Bioceramic Scaffolds with Antioxidative Functions for ROS Scavenging and Osteochondral Regeneration

Osteoarthritis (OA) is a degenerative disease that involves excess reactive oxygen species (ROS) and osteochondral defects. Although multiple approaches have been developed for osteochondral regeneration, how to balance the biochemical and physical microenvironment in OA remains a big challenge. In this study, a bioceramic scaffold by 3D printed akermanite (AKT) integrated with hair-derived antioxidative nanoparticles (HNPs)/microparticles (HMPs) for ROS scavenging and osteochondral regeneration has been developed. The prepared bioscaffold with multi-mimetic enzyme effects, which can scavenge a broad spectrum of free radicals in OA, can protect chondrocytes under the ROS microenvironment. Importantly, the bioscaffold can distinctly stimulate the proliferation and maturation of chondrocytes due to the stimulation of the glucose transporter pathway (GLUT) via HNPs/HMPs. Furthermore, it significantly accelerated osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). In vivo results showed that the bioscaffold can effectively enhance the osteochondral regeneration compared to the unmodified scaffold. The work shows that integration of antioxidant and mechanical properties via the bioscaffold is a promising strategy for osteochondral regeneration in OA treatment.

更新日期：2022-02-19

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南