The Synthesis of α-Keto Acetals from Terminal Alkynes and Alcohols via Synergistic Interaction of Organoselenium Catalysis and Electrochemical Oxidation,The Journal of Organic Chemistry

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The Synthesis of α-Keto Acetals from Terminal Alkynes and Alcohols via Synergistic Interaction of Organoselenium Catalysis and Electrochemical Oxidation
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2022-02-18 , DOI: 10.1021/acs.joc.1c02681
Ding Ding ₁ , Liang Xu ₁ , Yu Wei ₁

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Herein, an unprecedented electrochemical approach for the synthesis of α-keto acetals has been established from readily available terminal alkynes and alcohols. By merging the electrochemical and organoselenium-catalyzed processes, the desired products are obtained at room temperature in the absence of basic or metallic additives, with carbonyl and acetal motifs incorporated simultaneously across the triple bonds in a single operation.

中文翻译：

末端炔烃和醇通过有机硒催化和电化学氧化的协同作用合成α-酮缩醛

在这里，已经建立了一种前所未有的电化学方法来合成α-酮缩醛，该方法是从容易获得的末端炔烃和醇中获得的。通过合并电化学和有机硒催化过程，在没有碱性或金属添加剂的情况下，在室温下获得所需的产品，羰基和缩醛基序在一次操作中同时跨三键结合。

更新日期：2022-02-18

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