The existing information supports the use of this material as described in this safety assessment. Octyl isobutyrate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog hexyl isobutyrate (CAS # 2349-07-7) show that octyl isobutyrate is not expected to be genotoxic. Data on analog propyl (2S)-2-(1,1-dimethylpropoxy)-propanoate (CAS # 319002-92-1) provide a calculated Margin of Exposure (MOE) > 100 for the repeated dose and reproductive toxicity endpoints. Data from analog hexyl 2-methylbutyrate (CAS # 10032-15-2) provided octyl isobutyrate a No Expected Sensitization Induction Level (NESIL) of 7000 μg/cm² for the skin sensitization endpoint. Octyl isobutyrate is not expected to be phototoxic/photoallergenic based on ultraviolet/visible (UV/Vis) spectra. The local respiratory toxicity endpoint was evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material; exposure to is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; octyl isobutyrate was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.

现有信息支持使用本安全评估中描述的这种材料。评估了异丁酸辛酯的遗传毒性、重复给药毒性、生殖毒性、局部呼吸道毒性、光毒性/光过敏性、皮肤致敏性和环境安全性。来自模拟异丁酸己酯 (CAS # 2349-07-7) 的数据显示，异丁酸辛酯预计不会具有遗传毒性。模拟丙基 (2S)-2-(1,1-二甲基丙氧基)-丙酸酯 (CAS # 319002-92-1) 的数据提供了重复剂量和生殖毒性终点的计算暴露边际 (MOE) > 100。来自模拟 2-甲基丁酸己酯 (CAS # 10032-15-2) 的数据表明异丁酸辛酯的无预期致敏诱导水平 (NESIL) 为 7000 μg/cm ²为皮肤致敏终点。根据紫外/可见 (UV/Vis) 光谱，预计异丁酸辛酯不会产生光毒性/光致敏性。使用 Cramer I 类材料的毒理学关注阈值 (TTC) 评估局部呼吸毒性终点；暴露量低于 TTC（1.4 毫克/天）。评估了环境终点；根据国际香精协会 (IFRA) 环境标准及其风险商，基于其目前在欧洲和北美的使用量（即预测环境浓度/预计无影响浓度 [PEC/PNEC])，<1。