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A Metal-Phenolic Nanosensitizer Performs Hydrogen Sulfide-Reprogrammed Oxygen Metabolism for Cancer Radiotherapy Intensification and Immunogenicity
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-02-16 , DOI: 10.1002/anie.202200830 Jie Li 1, 2 , Lisi Xie 1, 3 , Wei Sang 1 , Wenxi Li 1 , Guohao Wang 1 , Jie Yan 1 , Zhan Zhang 1 , Hao Tian 1 , Quli Fan 4 , Yunlu Dai 1, 5
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-02-16 , DOI: 10.1002/anie.202200830 Jie Li 1, 2 , Lisi Xie 1, 3 , Wei Sang 1 , Wenxi Li 1 , Guohao Wang 1 , Jie Yan 1 , Zhan Zhang 1 , Hao Tian 1 , Quli Fan 4 , Yunlu Dai 1, 5
Affiliation
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A NIR-II fluorescence-traced metal-phenolic nanosensitizer was developed that performed H2S-reprogrammed oxygen metabolism for radiotherapy intensification and immunogenicity. Hf-PSP-DTC@PLX nanoparticles generate H2S under an acidic tumor microenvironment to inhibit mitochondrial respiration and reprogram oxygen metabolism for tumor oxygenation. The chelated Hf ions simultaneously make full use of the preserved oxygen to improve the generation of local reactive oxygen species against tumor cells and to trigger antitumor immune activation.
中文翻译：
金属酚类纳米增敏剂进行硫化氢重编程氧代谢以增强癌症放射治疗和免疫原性
开发了一种 NIR-II 荧光示踪金属酚类纳米增敏剂，该增敏剂进行 H 2 S 重编程氧代谢，用于放射治疗强化和免疫原性。Hf-PSP-DTC@PLX 纳米颗粒在酸性肿瘤微环境下产生 H 2 S 以抑制线粒体呼吸并重新编程肿瘤氧合的氧代谢。螯合的 Hf 离子同时充分利用保留的氧气来改善局部活性氧的产生，从而对抗肿瘤细胞并引发抗肿瘤免疫激活。
更新日期：2022-02-16
中文翻译：
金属酚类纳米增敏剂进行硫化氢重编程氧代谢以增强癌症放射治疗和免疫原性
开发了一种 NIR-II 荧光示踪金属酚类纳米增敏剂，该增敏剂进行 H 2 S 重编程氧代谢，用于放射治疗强化和免疫原性。Hf-PSP-DTC@PLX 纳米颗粒在酸性肿瘤微环境下产生 H 2 S 以抑制线粒体呼吸并重新编程肿瘤氧合的氧代谢。螯合的 Hf 离子同时充分利用保留的氧气来改善局部活性氧的产生，从而对抗肿瘤细胞并引发抗肿瘤免疫激活。
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