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Nanoengineered Neutrophils as a Cellular Sonosensitizer for Visual Sonodynamic Therapy of Malignant Tumors
Advanced Materials ( IF 27.4 ) Pub Date : 2022-02-17 , DOI: 10.1002/adma.202109969 Lei Sun 1, 2 , Jing-E Zhou 1 , Tengshuo Luo 1 , Jing Wang 1 , Liqing Kang 3 , Yeying Wang 1 , Shenggen Luo 1 , Zhehao Wang 1 , Ziyu Zhou 1 , Jiaxi Zhu 4 , Jiahui Yu 1 , Lei Yu 1 , Zhiqiang Yan 1
Advanced Materials ( IF 27.4 ) Pub Date : 2022-02-17 , DOI: 10.1002/adma.202109969 Lei Sun 1, 2 , Jing-E Zhou 1 , Tengshuo Luo 1 , Jing Wang 1 , Liqing Kang 3 , Yeying Wang 1 , Shenggen Luo 1 , Zhehao Wang 1 , Ziyu Zhou 1 , Jiaxi Zhu 4 , Jiahui Yu 1 , Lei Yu 1 , Zhiqiang Yan 1
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The rapid evolution of cell-based theranostics has attracted extensive attention due to their unique advantages in biomedical applications. However, the inherent functions of cells alone cannot meet the needs of malignant tumor treatment. Thus endowing original cells with new characteristics to generate multifunctional living cells may hold a tremendous promise. Here, the nanoengineering method is used to combine customized liposomes with neutrophils, generating oxygen-carrying sonosensitizer cells with acoustic functions, which are called Acouscyte/O2, for the visual diagnosis and treatment of cancer. Specifically, oxygen-carried perfluorocarbon and temoporfin are encapsulated into cRGD peptide modified multilayer liposomes (C-ML/HPT/O2), which are then loaded into live neutrophils to obtain Acouscyte/O2. Acouscyte/O2 can not only carry a large amount of oxygen but also exhibits the ability of long circulation, inflammation-triggered recruitment, and decomposition. Importantly, Acouscyte/O2 can be selectively accumulated in tumors, effectively enhancing tumor oxygen levels, and triggering anticancer sonodynamics in response to ultrasound stimulation, leading to complete obliteration of tumors and efficient extension of the survival time of tumor-bearing mice with minimal systemic adverse effects. Meanwhile, the tumors can be monitored in real time by temoporfin-mediated fluorescence imaging and perfluorocarbon (PFC)-microbubble-enhanced ultrasound imaging. Therefore, the nanoengineered neutrophils, i.e., Acouscyte/O2, are a new type of multifunctional cellular drug, which provides a new platform for the diagnosis and sonodynamic therapy of solid malignant tumors.
中文翻译：
纳米工程中性粒细胞作为恶性肿瘤视觉声动力治疗的细胞声敏剂
基于细胞的治疗诊断学的快速发展因其在生物医学应用中的独特优势而引起了广泛关注。然而，单靠细胞的固有功能并不能满足恶性肿瘤治疗的需要。因此，赋予原始细胞新特性以产生多功能活细胞可能具有巨大的前景。在这里，利用纳米工程方法将定制的脂质体与中性粒细胞结合，产生具有声学功能的载氧声敏细胞，称为Acouscyte/O 2，用于癌症的视觉诊断和治疗。具体而言，载氧全氟化碳和替莫泊芬被封装到 cRGD 肽修饰的多层脂质体（C-ML/HPT/O 2)，然后将其加载到活的中性粒细胞中以获得 Acouscyte/O 2。Acouscyte/O 2不仅可以携带大量氧气，而且具有长循环、炎症触发募集和分解的能力。重要的是，Acouscyte/O 2可以选择性地积聚在肿瘤中，有效提高肿瘤氧水平，并响应超声刺激触发抗癌声动力学，导致肿瘤完全消失，有效延长荷瘤小鼠的存活时间，全身副作用最小。同时，可以通过替莫泊芬介导的荧光成像和全氟化碳（PFC）-微泡增强超声成像对肿瘤进行实时监测。因此，纳米工程中性粒细胞Acouscyte/O 2是一种新型的多功能细胞药物，为实体恶性肿瘤的诊断和声动力治疗提供了新的平台。
更新日期：2022-02-17
中文翻译：
纳米工程中性粒细胞作为恶性肿瘤视觉声动力治疗的细胞声敏剂
基于细胞的治疗诊断学的快速发展因其在生物医学应用中的独特优势而引起了广泛关注。然而，单靠细胞的固有功能并不能满足恶性肿瘤治疗的需要。因此，赋予原始细胞新特性以产生多功能活细胞可能具有巨大的前景。在这里，利用纳米工程方法将定制的脂质体与中性粒细胞结合，产生具有声学功能的载氧声敏细胞，称为Acouscyte/O 2，用于癌症的视觉诊断和治疗。具体而言，载氧全氟化碳和替莫泊芬被封装到 cRGD 肽修饰的多层脂质体（C-ML/HPT/O 2)，然后将其加载到活的中性粒细胞中以获得 Acouscyte/O 2。Acouscyte/O 2不仅可以携带大量氧气，而且具有长循环、炎症触发募集和分解的能力。重要的是，Acouscyte/O 2可以选择性地积聚在肿瘤中，有效提高肿瘤氧水平，并响应超声刺激触发抗癌声动力学，导致肿瘤完全消失，有效延长荷瘤小鼠的存活时间，全身副作用最小。同时，可以通过替莫泊芬介导的荧光成像和全氟化碳（PFC）-微泡增强超声成像对肿瘤进行实时监测。因此，纳米工程中性粒细胞Acouscyte/O 2是一种新型的多功能细胞药物，为实体恶性肿瘤的诊断和声动力治疗提供了新的平台。
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