Nucleophilic aromatic substitution (S_NAr) reaction in classic textbook is a stepwise mechanism, and few examples of concerted reactions have been reported. Herein, we developed a concerted S_NAr reaction of 5-bromo-1,2,3-triazines with phenols in which the nonclassic mechanism of this reaction could be revealed by calculation. Furthermore, the resulting 5-aryloxy-1,2,3-triazines could be used as convenient precursors to access biologically important 3-aryloxy-pyridines in one-pot manner.

中文翻译：

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5-Bromo-1,2,3-triazines 与酚的亲核芳族取代

经典教科书中的亲核芳族取代（S _N Ar）反应是逐步机制，很少有协同反应的例子报道。在此，我们开发了 5-bromo-1,2,3-triazines 与酚类的协同 S _N Ar 反应，其中该反应的非经典机理可以通过计算揭示。此外，所得的 5-芳氧基-1,2,3-三嗪可用作方便的前体，以一锅法获得生物学上重要的 3-芳氧基-吡啶。