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Uniform Mesoporous Dye-Doped Silica Nanoparticles Decorated with Multiple Magnetite Nanocrystals for Simultaneous Enhanced Magnetic Resonance Imaging, Fluorescence Imaging, and Drug Delivery
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2010-01-20 , DOI: 10.1021/ja905793q Ji Eun Lee 1 , Nohyun Lee 1 , Hyoungsu Kim 1 , Jaeyun Kim 1 , Seung Hong Choi 1 , Jeong Hyun Kim 1 , Taeho Kim 1 , In Chan Song 1 , Seung Pyo Park 1 , Woo Kyung Moon 1 , Taeghwan Hyeon 1
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2010-01-20 , DOI: 10.1021/ja905793q Ji Eun Lee 1 , Nohyun Lee 1 , Hyoungsu Kim 1 , Jaeyun Kim 1 , Seung Hong Choi 1 , Jeong Hyun Kim 1 , Taeho Kim 1 , In Chan Song 1 , Seung Pyo Park 1 , Woo Kyung Moon 1 , Taeghwan Hyeon 1
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Highly versatile nanocomposite nanoparticles were synthesized by decorating the surface of mesoporous dye-doped silica nanoparticles with multiple magnetite nanocrystals. The superparamagnetic property of the magnetite nanocrystals enabled the nanoparticles to be used as a contrast agent in magnetic resonance (MR) imaging, and the dye molecule in the silica framework imparted optical imaging modality. Integrating a multitude of magnetite nanocrystals on the silica surface resulted in remarkable enhancement of MR signal due to the synergistic magnetism. An anticancer drug, doxorubicin (DOX), could be loaded in the pores and induced efficient cell death. In vivo passive targeting and accumulation of the nanoparticles at the tumor sites was confirmed by both T2 MR and fluorescence imaging. Furthermore, apoptotic morphology was clearly detected in tumor tissues of mice treated with DOX loaded nanocomposite nanoparticles, demonstrating that DOX was successfully delivered to the tumor sites and its anticancer activity was retained.
中文翻译：
用多个磁铁矿纳米晶体装饰的均匀介孔染料掺杂二氧化硅纳米粒子，用于同时增强磁共振成像、荧光成像和药物输送
通过用多个磁铁矿纳米晶体装饰介孔染料掺杂二氧化硅纳米粒子的表面，合成了高度通用的纳米复合纳米粒子。磁铁矿纳米晶体的超顺磁性特性使纳米颗粒能够用作磁共振 (MR) 成像中的造影剂，并且二氧化硅骨架中的染料分子赋予了光学成像模式。由于协同磁性，将大量磁铁矿纳米晶体集成在二氧化硅表面上导致 MR 信号显着增强。一种抗癌药物阿霉素（DOX）可以装载在毛孔中并诱导有效的细胞死亡。T2 MR 和荧光成像证实了纳米颗粒在肿瘤部位的体内被动靶向和积累。此外，
更新日期：2010-01-20
中文翻译：
用多个磁铁矿纳米晶体装饰的均匀介孔染料掺杂二氧化硅纳米粒子，用于同时增强磁共振成像、荧光成像和药物输送
通过用多个磁铁矿纳米晶体装饰介孔染料掺杂二氧化硅纳米粒子的表面，合成了高度通用的纳米复合纳米粒子。磁铁矿纳米晶体的超顺磁性特性使纳米颗粒能够用作磁共振 (MR) 成像中的造影剂，并且二氧化硅骨架中的染料分子赋予了光学成像模式。由于协同磁性，将大量磁铁矿纳米晶体集成在二氧化硅表面上导致 MR 信号显着增强。一种抗癌药物阿霉素（DOX）可以装载在毛孔中并诱导有效的细胞死亡。T2 MR 和荧光成像证实了纳米颗粒在肿瘤部位的体内被动靶向和积累。此外，
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