Objective 

This study aimed to evaluate and quantify the relationship between coffee and gastric cancer using a uniquely large dataset from an international consortium of observational studies on gastric cancer, including data from 18 studies, for a total of 8198 cases and 21 419 controls.

Methods 

A two-stage approach was used to obtain the pooled odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) for coffee drinkers versus never or rare drinkers. A one-stage logistic mixed-effects model with a random intercept for each study was used to estimate the dose–response relationship. Estimates were adjusted for sex, age and the main recognized risk factors for gastric cancer.

Results 

Compared to never or rare coffee drinkers, the estimated pooled OR for coffee drinkers was 1.03 (95% CI, 0.94–1.13). When the amount of coffee intake was considered, the pooled ORs were 0.91 (95% CI, 0.81–1.03) for drinkers of 1–2 cups per day, 0.95 (95% CI, 0.82–1.10) for 3–4 cups, and 0.95 (95% CI, 0.79–1.15) for five or more cups. An OR of 1.20 (95% CI, 0.91–1.58) was found for heavy coffee drinkers (seven or more cups of caffeinated coffee per day). A positive association emerged for high coffee intake (five or more cups per day) for gastric cardia cancer only.

Conclusions 

These findings better quantify the previously available evidence of the absence of a relevant association between coffee consumption and gastric cancer.

中文翻译：

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咖啡消费与胃癌：来自胃癌联合项目联盟的汇总分析

客观的 

本研究旨在评估和量化咖啡与胃癌之间的关系，使用来自国际胃癌观察研究联盟的独特大型数据集，包括来自 18 项研究的数据，共有 8198 例病例和 21419 例对照。

方法 

使用两阶段方法获得咖啡饮用者与从不或很少饮用者的汇总优势比 (OR) 和相应的 95% 置信区间 (CI)。使用每项研究的随机截距的单阶段逻辑混合效应模型来估计剂量-反应关系。根据性别、年龄和公认的胃癌主要危险因素对估计值进行了调整。

结果 

与从不或很少喝咖啡的人相比，咖啡饮用者的估计汇总 OR 为 1.03（95% CI，0.94-1.13）。当考虑咖啡摄入量时，每天喝 1-2 杯咖啡的合并 OR 为 0.91（95% CI，0.81-1.03），喝 3-4 杯的合并 OR 为 0.95（95% CI，0.82-1.10），以及0.95 (95% CI, 0.79–1.15) 对于五个或更多杯子。发现重度咖啡饮用者（每天七杯或更多杯含咖啡因的咖啡）的 OR 为 1.20（95% CI，0.91–1.58）。仅与胃癌的高咖啡摄入量（每天五杯或更多杯）呈正相关。

结论 

这些发现更好地量化了先前可用的证据，即咖啡消费与胃癌之间不存在相关关联。